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Development of drug for peritoneal carcinomatosis using angiogenic inhibitor.

Research Project

Project/Area Number 05557062
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

HAGIWARA Akeo  Kyoto Prefectural University of Medicine, Surgery 1, Lecturer, 医学部, 講師 (90198648)

Co-Investigator(Kenkyū-buntansha) SHIMOTSUMA Masataka  Kyoto Prefectural University of Medicine, Surgery 1, Assistant, 医学部, 助手 (30244601)
TAKAHASHI Toshio  Kyoto Prefectural University of Medicine, Surgery 1, Professor, 医学部, 教授 (50079828)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥3,300,000 (Direct Cost: ¥3,300,000)
Keywordsperitoneal carcinomatosis / angiogenic inhibitor / cancer metastases / chemotherapy / 剤形 / TNP-470 / ドラッグ・デリバリー・システム / マイクロスフェア
Research Abstract

Angiogenic inhibitors are expected as a new anti-cancer drug. It has not been confirmed that angiogenic inhibotors have therapeutic effects on peritoneal carcinomatosis. We examined the effects of one of the angiogenic inhibitors, TNP-470, on peritoneal carcinomatosis in mice.
TNP-470 in aqueous solution form showed a therapeutic effect when given in an early stage of the disease, while did not in advanced stages. The main side effect of the aqueous TNP-470 was accumulation of ascites induced through osmotic effects by emulsifying agent, sometimes generating a lethal toxicity.
TNP-MS,comprizing TNP-470 in the form of microspheres, was shown to be a dosage from preserving the drug activity, and TNP-MS releases the drug in an active from for a prolonged period of time, in the paritoneal cavity in animals. By these characteristics, TNP-MS achieved a therapeutic effect when administered in relatively advanced stages of peritoneal carcinomatosis in mice.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Masataka Shimotsuma: "Ontogeny of milky spots in the fetal lamb omentum" Arch. Histol. Cytol.57. 291-299 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 下間正隆: "腹膜播種性転移の予知とその対策" 日本消化器外科学会誌. 27. 983-986 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Therapeectic effects of the angiogenesis inhibitor TNP-470 agaiust carcinomatous peritonitis in mice." Anti-Cancer Drugs. 6. 438-442 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Site-specific implantation in the milky spots of malignant cells in peritoneal dissemination" Britsh J. of Cancer. 71. 468-472 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 辻本洋行: "血管新生阻害剤TNP-470による癌性腹膜炎の治療" 癌と化学療法. 11. 1527-1529 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masataka Shimotsuma: "Ontogeny of milky spots in the fetal lamb omentum." Arch.Histol.Cytol.57. 291-299 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masataka Shimotsuma: "Presumes and management of peritoneal dissemination of cancer." Nihon-Shokaki-Geka-Gakkaishi. 27. 983-986 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Therapeutic effects of the angiogenesis inhibitor, TNP-470 against carcinomatous peritonitis in mice." Anti-Cancer Drugs. 6. 438-442 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Site-specific implantation in the milky spots of malignant cells in peritoneal dissemination." British J.Cancer. 71. 468-472 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Chemotherapy for peritoneal carcinomatosis using angiogenic inhibitor TNP-470." Gan-to-Kagakuryouhou. 11. 1527-1529 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroyuki Tsujimoto: "Therapeutic effects of the angiogenesis inhibitor TNP-470 against carcinomatous peritomtis in mice" Anti-Cancer Drags. 6. 438-442 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroyuki Tsujimoto: "Site-specific implantation in the milkyspots of malignant cells in peritoneal dissemination" British J.Cancer. 71. 468-472 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 辻本洋行: "血管新生阻害剤TNP-470による癌性腹膜炎の治療" 癌と化学療法. 11. 1527-1529 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 萩原明於: "癌治療におけるドラッグデリバリーシステム" 外科治療. 71. 197-204 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 尾崎公彦他10名: "血管新生阻害剤TNP-470を用いた癌性腹膜炎の治療" 癌と化学療法. 20. 1575-1577 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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