| Project/Area Number |
05557075
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
TANO Yasuo Osaka University, Department of Ophthalmology, Professor, 医学部, 教授 (80093433)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Takehisa National Cardiovascular Center, Department of Bioengineering, Chief, 生体工学部, 部長 (60142189)
ISHIMOTO Ichiro Osaka University, Department of Ophthalmology, Instructor, 医学部, 講師 (80159780)
檀上 真次 大阪大学, 医学部, 講師 (80183474)
岸田 健一 大阪大学, 医学部, 講師 (80028563)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1994: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | Photo-crosslink / Hyaluronic Acid / Thymine / Chondroitin Sulfate / Cinnamic Acid / Adhesion Prevention / Conjunctiva / Vitreous |
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| Research Abstract |
Scarring response and adhesion formation beneath the conjunctiva cause various postoperative problems in glaucoma, strabismus or retinal detachment surgery. The newly developed photo-crosslinkable mucopolysaccharides, i.e.tyminated hyaluronic acid (TH) and cinnamated hyaluronic acid (CH), form water insoluble membranes when exposed to light. TH and CH membranes have nonadhesive surface characteristics and degrade in vivo. These properties may make them suitable for use as antiadhesive membranes. This study examines the efficacy of photo-crosslinked hyaluronic acid membranes to prevent conjunctivo-scleral adhesion after surgery. In our experiments using rabbits, CH and TH membranes both effectively reduced postoperative conjunctival adhesions. On the other hand, large peripheral retinotomies have been done to treat choroidal neovascular membranes, however they may predispose patients to develop proliferative retinopathy and neovascular glaucoma. It is insisted on the importance to cover the retinotomy site with biocompatibel materials. In this study, we also attempt to develop a nobel technique to seal retinal holes using photocrosslinkable mucopolysaccharide solutions and an optical fiber scope to introduce light into the vitreous cavity. The technique to crosslink mucopolysaccharides by light exposure is worthy of further investigation.
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