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The Study on Seaching for the Biologically Active Compounds Containd in the Medicinal Plants

Research Project

Project/Area Number 05557097
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionUniversity of Tokyo

Principal Investigator

SANKAWA Ushio  University of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (60012613)

Co-Investigator(Kenkyū-buntansha) SATO Toshitsugu  Tsumura Phamaceutical Company Institution of Pharmacology, Head Researcher, 研究所, 研究員
SHIBUYA Masaaki  University of Tokyo, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (50170923)
NOGUCHI Hiroshi  University of Tokyo, Faculty of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 (60126141)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 1994: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1993: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsBiologically Active Compound / Screening / Anti-PAF / Anti-Allergy / Lignan / Stillbene / Flavone / Ca Antagonist
Research Abstract

We have been investigated the biologically active compounds contained in more than two-hundred of the medicinal plants and plant origin crude drugs obtained in Japan, China, Taiwan, Hong-Kong, Indonesia and other country of southeast Asia, using the in vitro bioassay system. We found that many of the compounds which had anti-allergy activity had two aromatic rings such as lignan, stillbene and flavone. The distance and direction of two benzene ring are supposed to be very important for ant-allergy activity. On the bases of such structure-activity relationship, the eleven compounds having the two benzene ring which were connected by amide bond such as the product of the coupling of benzylamine and benzoic acid. The synthesized compounds were tested for repression of histamine release activity and anti-platelet aggregation activity. Some of the synthesized compounds revealed significant activity. The testing of in vivo activity are under investigation.
Fissistigma oldhamii(Memsl.)Merr.(Annonaceace)is a perennial shrub which is distributed mainly in southern China and Taiwan. In a preliminary bioassay, its methanol extract showed anti-platelet aggregation activity and its constituents were investigated in the plant material collected in Taichung, Taiwan. A new alkaloid of hydro-oxadiazine with four-ring fused structure has been isolated and named fissoldhimine, the structure of which was solved by X-ray analysis. The detail of biological activities of fissolidhmine is under investigation.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Jin-Bin Wu 他: "Fissolhimine, A Novel Skeleton Alkaloid from Fissisigma oldhamii" Chem. Pharm. Bull. 42. 2202-2204 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song 他: "Elicitors Which Induce the Accumulation of p-Coumaryl Amino Acids in Ephedca distachta Cultures" Arch. Pharm. Res.17. 26-30 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song 他: "p-Coumaric Acids from Yeast-Elicited Ephedra distachya Cultures" Arch.Pharm.Res.17. 48-50 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song 他: "A Novel Benzoic Acid Derivative from Yeast-Elicited Ephedra distachya Cultures" Arch. Pharm. Res.17. 54-55 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 渋谷雅明: "高等植物により得られる抗腫瘍活性物質" 植物細胞工学. 6. 109-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 三川 潮: "薬用植物成分と医薬品開発" 植物細胞工学. 6. 118-127 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jin-Bin Wu, Yih-Dih Cheng, Shen-Chu Kuo, Tian-Shung Wu, Yoichi Iitaka, Yutaka Ebizuka and Ushio Sankawa: "Fissolhimine, a Novel Skeleton Alkaloid from Fissisigma oldhamii" Chem.Pharm.Bull.42. 2202-2204 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song, Ushio Sankawa and Yutaka Ebizuka: "Elicitors Which Induce the Accumulation of p-Coumaroyl Amino Acids in Ephedra distachya Cultures" Arch.Pharm.Res.17. 26-30 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song, Ushio Sankawa and Yutaka Ebizuka: "p-Coumaric Acids from Yeast-Elicited Ephedra distachya Cultures" Arch.Pharm.Res.17. 48-50 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kyung-Sik Song, Ushio Sankawa and Yutaka Ebizuka: "A Novel Benzoic Acid Derivative from Yeast-Elicited Ephedra distachya Cultures" Arch.Pharm.Res.17. 54-55 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hideji Itokawa, Masaaki Shibuya: "Antineoplastic Agents from Higher Plants" Plant Cell Technology. 6. 109-117 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ushio Sankawa: "Medicinal Plant Constituents and Drug Development" Plant Cell Technology. 6. 118-127 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jin-Bin Wu,他: "Fissolhimine,A Novel Skeleton Alkaloid from Fissisigma oldhamii" Chem.Pharm.Bull. 42. 2202-2204 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kyung-Sik Song,他: "Elicitors Which Induce the Accumulation of p-Coumaryl Amino Acids in Ephedra distachya Cultures" Arch.Pham.Res.17. 26-30 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kyung-Sik Song,他: "p-Coumaric Actds from Yeast-Elicited Ephedra distachya Cultures" Arch.Pharm.Res.17. 48-50 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kyung-Sik Song,他: "A Novel Benzoic Acid Derivattve from Yeast-Ekcited Ephedra distachya Cultures" Arch.Pharm.Res.17. 54-55 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 渋谷雅明: "高等植物より得られる抗腫瘍活性物質" 植物細胞工学. 6. 109-117 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 三川潮: "薬用植物成分し医薬品開発" 植物細胞工学. 6. 118-127 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 渋谷雅明 他: "Probing Ergot Alkaloid Bisynthesis" J.Amer Chem.Soc. 115. 2482-2488 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 三川潮 他: "Recent Progress in Studies of the Biosynthesis of Isoflavonoids" J.Plant Research,Special Issue No3. 129-144 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 三川潮 他: "Post-Aromatic Deoxygenation in Polyketide Biosynthesis" Chem.Pharm.Bull. 41. 2015-2021 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 三川潮: "薬用植物と医薬品開発" 植物・細胞工学. 5(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 渋谷雅明 他: "抗腫瘍性植物成分" 植物細胞工学. 5(印刷中). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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