| Project/Area Number |
05557109
|
|---|
| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
医薬分子機能学
|
|---|
| Research Institution | University of Tokyo, Faculty of pharm.Sciences |
|---|
Principal Investigator |
SHUDO Koichi The University.of Tokyo Fac.Pharm.Sci.Propessor, 薬学部, 教授 (50012612)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAGECHIKA Hiroyuki The University.of Tolyo Fac.Pharm.Sci.Assostant Prof., 薬学部, 助手 (20177348)
大和田 智彦 東京大学, 薬学部, 助手 (20177025)
橋本 祐一 東京大学, 分子細胞生物学研究所, 助教授 (90164798)
遠藤 泰之 東京大学, 薬学部, 助教授 (80126002)
|
|---|
| Project Period (FY) |
1993 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥17,900,000 (Direct Cost: ¥17,900,000)
Fiscal Year 1995: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1994: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1993: ¥10,300,000 (Direct Cost: ¥10,300,000)
|
|---|
| Keywords | retinoid / tyroids / retinoic acid / differentiation / HL60 / leukemia / myeloma / antagonist synergist / レチノイドアンタゴニスト / レチノイン酸レセプター / チロイドリセプター / 腫瘍悪性化 / アンタゴニスト / チロキシン / フオルボール / ジベンゾジアゼピン / 癌 / ベンゾラクタム |
|---|
| Research Abstract |
New retinoids and steroids, tyroids are designed and synthesized. Methods for a divergent reaction were illustrated. Tyroids with trifluoromethyl group were proved to be active. Retinoids syhnthesized proviously were proved to be a candidate for the treatment of acute promyelocytic leukemia and for the treatment of arthrites rheumatoid. 4 [5H-2,3- (2,5-dimethy12,5-jexano-5-methyldibenzodiazepin-1-ylbenzpic acid enhanced the differentiation inducing activity of retinoic acid and of a synthetic retinoid Am80 toward human promyelocytic leukemia cells, although the compound itself did not induce differentiation. The synergedstic effect of the compound was also seen in supression of HL60 cells.
|
