| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
The unterus and vagina of ovarimized mice expressed higher levels of proto-oncogene mRNA,c-jun and c-fos mRNAs, by estradiol and tamoxifen, resulting in DNA synthesis and proliferation of female genital tracts. n the GR/A mouse which is characterized by the development of pregnancy-dependent mammary tumors (PDMT), growth of PDMT were dominated by hormonal levels resulting from the activity of c-jun, c-fos and EG ganes. In female and male mouse reproductive tracts, a decrease in Bcl-2, suppressor of apoptosis, occurred before the translation of Fas mRNA,suggesting that Bcl-2 directly or indirectly participates in a translation of Fas mRNA.
Estrogen, progesterone, EGF and TGFalpha were effective in stimulating the proliferation in vitro of placental trophoblastic cells from early pregnancy, but were ineffective in doing the proliferation of decidual cell.Immunohistochemical investigation demonctrated in female rats that progesterone receptor (PR) expression in the uterus and vagina was regulated by ovarian steroids during the estrous cycles and early pregnancy. The appearance of PR in rat uterus was controlled by factors other than endogenopus estrogen. The uterine response to the steroids, e.g., mitotic activity PR expression and protein synthesis in the endometrial cells, was markedly affected in neonatally androgenized rats, which is responsible for the lowered decidual response in these animals.
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