| Project/Area Number |
05660137
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
食品科学・栄養科学
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KAWADA Teruo Kyoto Univ., Agric., Asoc.Plof., 農学部, 助教授 (10177701)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Fatty acids / Gone exphessiem / Lipid metabolism / Obesity / Adipose cells / Thans criptional factor / Signal transoluction / ビタミンD受容体 / レチノイン酸受容体 / 脂肪酸結合タンパク質 |
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| Research Abstract |
It is important to the improvement of human health that the positive and negative regulatory systems for the signal transduction of fatty acids be well defined. Recently, fatty acids itself may act as a rigands signals to directly terget genes, and the results regulate the transcriptional control of genes on lipid metabolism and related events. In the present study, we have decided to systematically examine the effects of these fat soluble vitamins and their analogs on terminal differentiation from preadipocytes to adipocytes on the cellular and molecular aspects. The effects of RA and 1,25-OH2D3 are believed to be mediated by a specific nuclear receptor protein [retinoic acid receptor (RAR) ; designated ad subtypes alpha, beta and gamma, vitamin D receptor (VDR) ] which are members of the steroid and thyroid/retinoid receptor superfamily of ligand dependent transcriptional regulators. Furthermore, I revealed the membran asociated fatty acids receptor (mFAR) in the small intestine in rats. mFAR acts as a recognition molecule of long chain fatty acids on the signal transduction of regulatory systems for genes.
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