| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Research Abstract |
This study examined the effects of hypoxia on the gastric function in conscious rats in a series of experiments. Hypoxia delayd the excretion rats of urinary urea until after 12h of hypoxia and the delay was more remarkable in rats subjected to 7.6%O_2 hypoxia than in those subjected to 10.5%O_2 hypoxia. In Experiment 2, when rats fed the high protein diet for 4h were exposed to 7.6%O_2, a delay in gastric emptying was found in the hypoxic rats. In Experiment 3, when rats fed the normal protein diet for 4h were exposed to 7.6%O_2 hypoxia, the rats of urea excretion in the hypoxic rats were not significantly different from that in the normoxic rats until after 24h of hypoxia. However, rats fed the normal protein diet for 4h werecaused a delay of gastric emptying by 10.5%O_2 hypoxia. In Experiment 4, when rats fed the high protein diet for 4h were exposed to 7.6%O_2 or 10.5%O_2 hypoxia, the plasma gastrin concentration in the 7.6%O_2 hypoxic rats was 2.3-fold that in the normoxic rats after 6h of hypoxia although the gastrin level did not differ between the 10.5%O_2 hypoxic and the normoxic rats during 6h of hopoxia. Furthermore, when food-deprived rats were exposed to 7.6%O_2 or 10.5%O_2 hypoxia, the gastrin concentration was higher in both hypoxic groups than in the normoxic group after 3h of hypoxia. In Experiment 5, food-deprived rats with pylous ligation were exposed to 7.6%O_2 or 10.5%O_2 hypoxia for 3h. Both hypoxia inhibited the secretion of gastric acid and stimulated the gastrin release. In Experiment 6, food-deprived rats with pylorus ligation were orally administered HC1 and then exposed to 7.6%O_2 hypoxia for 3h. The rise of the gastrin concentration due to hypoxia was completely inhibited by the oral administration of HC1. These results demonstrate that hypoxia inhibits gastric emptying and secretion and that the inhibitory effect of hypoxia on gastric acid secretion stimulates gastrin release through positive feedback regulation.
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