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THE EFFECTS OF TRICHOTHECENE(T-2 TOXIN)IN THE INTESTINAL IMMUNITY AND THE SENSITIVITY TO LISTERIOSIS.

Research Project

Project/Area Number 05660150
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 食品科学・栄養科学
Research InstitutionNATIONAL INSTITUTE OF HEALTH OF JAPAN

Principal Investigator

SUGITA-KONISHI Yoshiko  NATIONAL INSTITUTE OF HEALTH,DEP.OF BIOMEDICAL FOOD RESEARCH RESEARCHER, 食品衛生微生物部, 研究員 (10195761)

Co-Investigator(Kenkyū-buntansha) INOUE Satoshi  NATIONAL INSTITUTE OF HEALTH,DEP.OF VETERINARY SCIENCE RESEACHER, 獣医科学部, 研究員 (90213157)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsTRICHOTHECENE / LISTERIOSIS / IMMUNOCOMPETENT CELLS / EXPOSURE / TNF-alpha / INF-gamma / トリコテセン / 免疫担当細胞 / 腸管細胞 / IFN-γ / マクロファージ / T-2トキシン / Caco-2 / フローサイトメトリー / T細胞 / B細胞 / 脾臓 / 胸腺 / 腸リンパ節
Research Abstract

In the first year, the effects of trichothecene(T-2 toxin)on the immunocompetent cells were examined. The short term-exposure with middle or high dose of T-2 toxin caused the decrease of weights and the number of T cells, B cells in thymus, spleen and blood. On the hand, the long term-exposure with low does induced the change of the population of the immunocompetent cells in the lympocytes in intestine. This result suggests that even the exposure with low does of T-2 toxin has the risk of the gastrointestinal infection.
In the last year, the effects of T-2 toxin on the sensitivity to listeriosis were examined. The mice exposured with middle dose of T-2 toxin showed the resistance to listeriosis though those immunocompetent cells were decreased. The production of TNF-alpha and INF-gamma in those mice rised than in no treatment mice. This result indicated the short term-exposure with trichothecene enhances the production of cytokines and then induces the acquisition the resistance to listeriosis.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 小西良子: "The effets of dietay T-2 toxin on immunopompetent cells and their functions." Proceedings of Japanese Society of Animal Biochemistry. 30. 65-74 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小西良子: "The cytotoxicity of Macrocyclic Trichothecenes,Roridin A and Verrucarin A on murine T-cells is reduced by Ia-negative splenic adherent cells." Toxicon. 32. 1051-1057 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小西 良子: "The effects of dietary T-2 toxin on immunocompe tent cells" Proceedings of Japanese Society of Animal Biochewistry. 30. 65-74 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小西 良子: "The cyto toxicity of Macrocy clic Tricho thecenes,Roridin A and Verrucarin A,on murine T-cells is reduced by Ia-negative splenic adnerent cells" Toxicon. 32. 1051-1057 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小西良子: "The effects of diefary T-2 toxin on immunocompetent cells and their functions" Proceedings of Japanese Societyof Animal Biochemisty. 30. 65-74 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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