Central peptidergic neuron regulating gastric acid secretion
Project/Area Number |
05670063
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Niigata University |
Principal Investigator |
SAKAGUCHI Takeo Niigata University School of Medicine Department of Physiology Assistant Professor, 医学部, 助手 (40108022)
|
Project Period (FY) |
1993 – 1994
|
Project Status |
Completed (Fiscal Year 1994)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
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Keywords | Acid secretion / Gastric function / Paraventricular nucleus / Hypothalamus / Medulla oblongata / Sexual difference / Peptidergic neuron |
Research Abstract |
Gastric acid outputs were examined after gastrin-17 (gastrin) or oxytocin injection into either side of the hypothalamic paraventricular nucleus (PVN) or both sides of the PVN in bilaterally adrenalectomized rats. The acid output increased when picomolar gastrin was unilaterally injected into the PVN,and an additive increase in the acid output was elicited when and effective concentration of gastrin was simultaneously injected into both sides of the PVN.Almost the same magnitude of acid response due to PVN gastrin was reproduced in normoglycemia, but it was diminished in hyperglycemia. While the acid output enhanced by insulin decreased when nanomolar oxytocin was unilaterally injected into the PVN,and an additive decrease in the acid output was elicited when an effective concentration of oxytocin was injected into both sides of the PVN simultaneously. Almost the same magnitude of acid response due to PVN oxytocin was reproduced in hypoglycemia, but the acid response was diminished in hyperglycemia. It was also noted that acid response caused by oxytocin was minimal when 17-beta estradiol was applied to rats with bilateral ovariectomy. These results suggest that PVN neurons sensitive to gastrin or oxytocin form a neural circuit in both sides of the nucleus, and the circuit acts to potentiate the stimulation of gastric acid which is dependent on the glycemic condition or the estrus cycle.
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Report
(3 results)
Research Products
(17 results)