| Project/Area Number |
05670072
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
FURUYAMA Fujiya Nagoya City University Medical School, lecturer, 医学部, 講師 (00080101)
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| Co-Investigator(Kenkyū-buntansha) |
NISHINO Hitoo Nagoya City University Medical School, Professor, 医学部, 教授 (60073730)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | body temperature regulation / heat resistance / rats / stress / cold resistance / inbred / hyperthermia / adaptation / hyperthermia / body temperature / cell injury / brain / salivary glands / inbred rats FOK / genotypic adaptation / resistance adaplation |
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| Research Abstract |
I.Further purification of the FOK rat strain
FOK rats had been selected by heat resistance and sibmated up to 40th generation in total. On the other hand, FOK rats were born by caesarean section into disinfected vinylene-isolator. They were gave milk by SPF foster mother. It was demonstrated by quarantine that pups had no specific pathogens. Thus, it became possible to keep FOK rat as a SPF animal and send it safely to other institute.
II.The effects of hyperthermia
During hyperthermia higher than 40ﾟC,common rats salivate. FOK rats secreted saliva for 300 min in spite of severe dehydration, although other rats secreted small amount of saliva only for 30-120min. On the other hand, at 33ﾟC body temperature in FOK rat was lower than those in other rat strains, although these rats did not salivate in response to heat. Thermogenesis in brown adipocyte in FOK rat was lower during hyperthermia in vitro than those in other rat strains. These findings suggested possible mechanism contributing to diminish body temperature rising in FOK rat besides thermal salivation. Dark neurons were found in ischemic areas and other areas distant from ischemic areas.
III.Congenital changes in consequence of genetic resistance adaptation to heat
At 24ﾟC body temperature in FOK rat was lower than those in other rat strains. Submandibular salivary glands in FOK rat were enlarged. FOK rat was also cold resistant rat.
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