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STUDIES ON A MODEL FOR MULTI-INFARCT DEMENTIA

Research Project

Project/Area Number 05670106
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionTOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCE

Principal Investigator

TAKEO Satoshi  TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCE.PROFESSOR, 薬学部, 教授 (00136722)

Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
KeywordsAcetycholine / Cerebral ischemia / Dopamine / Microsphere embolism / Learning task / Multi-infarct Dementia / Norepinephrine / Serotonin / マイクロスフェア / 多発梗塞 / 痴呆症 / 線条体 / マイクロダイアリシス / 脳血流 / コリン / グルタメート / アスパルテート
Research Abstract

This study was designed to elucidate pathophysiological alterations of microsphere-embolized rats, which may mimic multi-infarct dementia. Microspheres (48mum in diameter) were injected to the right internal carotid artery and the animals with stroke-like symptoms were used for the study. Microsphere embolism induced a decrease in blood flow of regional brains including the cerebral cortex, striatum and hippocampus of the animals. In association with this alteration, we observed the decrease in acetylcholine, amino acid, and monoamines such as norepinephrine, dopamine and serotonin of the three brain regions of the microsphere-embolized rats. Histological study also showed a decrease in the length of choline-acetyl transferase-containing fibers, but not the number of cell body. Learning task of the microsphere-embolized animal was examined using passive and active avoidance, and water maze tests, and found to be severely impaired. These results suggest that microsphere-embolized rats induce multi-infarct dementia-like symptoms. The effects of naftidrofuryl oxalate, a cerebral vasodilator, on the pathophysiological alterations of the microsphere-embolized rats were examined. Several improvements such as the reduction in the cortical cerebral blood flow and the partial reverse in acetylcholine, dopamine and serotonin contents, were detected. The results suggest that this model is useful for evaluation of agents which might be beneficial for multi-infarct-induced failure in learning task in animals.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Taguchi T.,Miyake K.Tanonaka K.,Okada M.,Takagi N.,Fujimori K.,Takeo S.: "Sustained changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats." Japanese Jouranal of pharmacology. 62. 269-278 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyake K.,Takagi N. Takeo S.: "Effects of naftidrofuryl oxalate on microsphere embolism-induced decrease in regional blood flow of rat brain." British Jouranal of pharmacology. 112. 226-230 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taguchi T.,Takagi N. Miyake K.,Tanonaka K. Okada M.,Kajihara H. Takeo S.: "Effects of naftidrofuryl oxalate on Microsphere-induced changes in acetylcholine and amino acid content of rat brain regions." Exper imental Brain Research. 99. 7-16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N.,Tsuru H. Yamamura M.,Takeo S.: "Changes in striatal dopamine metabolism after microsphere embolism in rats." Stroke. 26. 1101-1106 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N.,Miyake K. Ohiwa A.,Nukaga R. Takeo S.: "Effects of delayed treatment with nafronyl oxalate on microsphere embolism-induced changes in monoamine levels of rat brain regions." British Journal of pharmacology. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N.,Miyake K. Taguchi T.,Sugita N. Takagi K.,Tamada H. Takeo S.: "Changes in cholinergic neurons and failure in learning function after microsphere embolism-induced cerebral ischemia." Brain Research Bulletin.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N.,Miyake K. Taguchi T.,Tamada H. Takagi K.,Sugita N. Takeo S.: "Failure in learning task and loss of cortical cholinergic fibers in microsphere-embolized rats." Exper imental Brain Research.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taguchi T., Miyake K., Tanonaka K., Okada M., Takagi N., Fujimori K., Takeo S.: "Sustained changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats." Japan. J.Pharmacol.62. 269-278 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyake K., Takagi N., Takeo S.: "Effects of naftidrofuryl oxalate on microsphere embolism-induced decrease in regional blood flow of rat brain." Br. J.Pharmacol.112. 226-230 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taguchi T., Takagi N., Miyake K., Tanonaka, K., Okada M., Kajihara H., Takeo S.: "Effects of naftidrofuryl oxalate on Microsphere-induced changes in acetylcholine and amino acid content of rat brain regions." Exp. Brain Res.99. 7-16 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N., Tsuru H., Yamamura M., Takeo S.: "Changes in striatal dopamine metabolism after microsphere embolism in rats" Stroke. 26. 1101-1106 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N., Miyake K., Ohiwa A., Nukaga R., Takeo S.: "Effects of delayd treatment with nafronyl oxalate on microsphere embolism-induced changes in monoamine levels of rat brain regions" Br. J.Pharmacol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N., Miyake K., Taguchi T., Sugita N., Takagi K., Tamada H., Takeo S.: "Changes in cholinergic neurons and failure in learning function after microsphere embolism-induced cerebral ischemia." (Submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagi N., Miyake K., Taguchi T., Tamada H., Takagi K., Sugita N., Takeo S.: "Failure in learning task and loss of cortical cholinergic fibers in microsphere-embolized rats." (Submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taguchl T.: "Sustalned changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats." Japanese Journal of Pharmacology. 62. 269-278 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Miyake K.: "Effects of naftidrofuryl oxalate on microsphere embolism-induced decrease in regional blood flow of rat brain." British Journal of Pharmacology. 112. 226-230 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Taguchi T.: "Effects of naftidrofuryl oxalate on Microsphere-induced changes in acetylcholine and amino acid content of rat brain regions." Experimental Brain Research. 99. 7-16 (1984)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takagi N.: "Changes in striatal dopamine metabolism after microsphere embolism in rats." Stroke. 26. 1101-1106 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takagi N.: "Effects of delayed treatment with nafronyl oxalate on microsphere embolism-induced changes in monoamine levels of rat brain regions." British Journal of Pharmacology. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Taku Taguchi: "Effects of naftidrofuryl oxalate on microsphere-induced changes in acetylcholine and amino acid content of rat brain regions" Exp.Brain Res.99. 7-16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Miyake K.,Takagi N.,Takeo S.: "Effects of Naftidrofuryl Oxalate on Microsphere Embolism-Induced Decrease in Regional Blood Flow of Rat Brain" British Journal of Pharmacology. (印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] Taguchi T.,Takagi N.,Miyake K.,Tanonaka K.,Okada M.,Kajihara H.,Takeo S.: "Effects of Naftidrofuryl Oxalate on Microsphere-induced Changes in Acetylcholine and Amino Acid Content of Rat Brain Regions" Experimental Brain Research. 印刷中.

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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