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BIOLOGICAL MONITORING OF EXPOSURE TO TOXIC SUBSTANCES USING IMMUNOLOGICAL INDICES

Research Project

Project/Area Number 05670337
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionThe UNIVERSITY OF TOKYO

Principal Investigator

SATA Fumihiro  UNIVERSITY OF TOKYO, FACULTY OF MEDICINE, INSTRUCTOR, 医学部(医), 助手 (90187154)

Co-Investigator(Kenkyū-buntansha) TANIGAWA Takeshi  UNIVERSITY OF TOKYO, FACULTY OF MEDICINE, INSTRUCTOR, 医学部(医), 助手 (80227214)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsImmunological indices / Biological monitoring / Lead / Toluene / Lymphocyte subpopulations / T cells / Natural killer cells / Immunoglobulins / 有機溶剤 / リンパ球サブセット / ナチュラル・キラー細胞 / CD4^+CD45RA^+細胞 / 鉛曝露 / フローサイトメトリー
Research Abstract

To evaluate the immunological effects of occupational exposure to lead and organic solvents, we carried out the following studies and got those findings.
1. We measured immunoglobulins, lymphocyte subpopulations and other lead-related indices in two male lead workers, to whom calcium disodium ethylenediamine tetraacetate (CaEDTA) was administrated three times a week. Significant increases in IgG, IgA, IgM, CD8+ and CD57+ cells in one worker and a significant increase in IgD in another after CaEDTA injection were found. There was a significant negative correlation between PbB and IgG in one worker. It is suggested that the immunological function such as antibody formation in lead workers might be improved by CaEDTA injection.
2. We analyzed lymphocyte subpopulations in 29 male lead stearate workers and found a significant reduction of CD16+ natural killer (NK) cells in the high PbB group (【greater than or equal】20 μg/dl). There was significant negative correlation between the number of CD16+ cells and PbB. It is suggested that the CD16+ NK cell should be a major site of the effects of lead on lymphocyte subpopulations.
3. We analyzed T cell subpopulations in 71 male lead stearate workers and found a significant reduction in the number of CD3+CD45RO+ (memory T) cells. There was a significant positive correlation between the percentage of CD3+CD45RA+ (naive T) cells and PbB. It is suggested that CD45RO+ memory T cells may be susceptible to the effects of lead on T cell subpopulations.
4. We analyzed lymphocyte subpopulations in 16 male rotogravure printers workers exposed to toluene and found reductions in numbers of all NK cell subpopulations, CD4+CD45RA+ and CD8+ cells, an expansion in the number of B cells at the end of weekdays and their associations with blood toluene levels. It is suggested that numbers of those cells might be altered by the effects of toluene.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Sata F,Araki S,Sakai T,Nakata A,Yamashita K,Morita Y,Tanigawa T,Miki A.: "Immunological effects of CaEDTA injection:observations in two lead workers"Am J Ind Med. 32. 674-680 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F,Araki S,Sakai T,Yamashita K,Nakata A,Tanigawa T,Miki A,Morita Y.: "Effects of CaEDTA injection on immunological and heme-related indices:observations in tow lead workers"Plezensky Lekarsky Sbornik. suppl.71. 105-106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F,Araki S,Tanigawa T,Morita Y,Sakurai S,Katsuno N.: "Changes in natural killer cell subpopulations in lead workers"Int Arch Occup Environ Health. 69. 306-310 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F,Araki S,Tanigawa T,Morita Y,Sakurai S,Nakata A,Katsuno N.: "Changes in T cell subpopulations in lead workers"Environ Res. 76. 61-64 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tanigawa T,Araki S,Nakata A,Yokoyama K,Sata F,Murata K,Sakai T,Sakurai S.: "Assessment of lymphocyte subpopulations in rotogravure printers"発表予定(投稿中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F, Araki S, Sakai T, Nakata A, Yamashita K, Morita Y, Tanigawa T, Miki A: "Immunological effects of CaEDTA injection : observations in two lead workers."Am J Ind Med. 32(6). 674-680 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F, Araki S, Sakai T, Yamashita K, Nakata A, Tanigawa T, Miki A, Morita Y: "Effects of CaEDTA injection on immunological and heme-related indices : observations in two lead workers."Plezensky Lekarsky Sbornik, Supplement. 71. 105-106 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F, Araki S, Tanigawa T, Morita Y, Sakurai S, Katsuno N: "Changes in natural killer cell subpopulations in lead workers."Int Arch Occup Environ Health. 69(5). 306-310 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sata F, Araki S, Tanigawa T, Morita Y, Sakurai S, Nakata A, Katsuno N: "Changes in T cell Subpopulations in lead workers."Environ Res. 76(1). 61-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tanigawa T, Araki S, Nakata A, Yokoyama K, Sata F, Murata K, Sakai T, Sakurai S: "Assessment of lymphocyte subpopulations in rotogravure printers."(Submitted.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐田文宏: "鉛作業者の免疫学的研究" 産業医学. 35. S454 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐田文宏: "鉛作業者の免疫影響に関する研究-CD4^+CD45RA^+T細胞の減少について-" 日本衛生学雑誌. 48. 419 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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