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Epidemiological, clinical and experimental study on neurological, psychological and behavioral disturbances induced by alcohol.

Research Project

Project/Area Number 05670338
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionUniversity of Tokyo

Principal Investigator

YOKOYAMA Kazuhito  University of Tokyo, School of Medicine, Associate Professor, 医学部(医), 助教授 (00158370)

Co-Investigator(Kenkyū-buntansha) MURATA Katsuyuki  University of Tokyo, School of Medicine, Instructor, 医学部(医), 助手 (80157776)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsDrinking / Alcobol dependency / neurobehaviard effects / Sobriety / Reasons / Self-help group / 神経、精神および行動障害 / 神経,精神および行動障害
Research Abstract

Epidemiological, clinical and experimental studies were carried out on neurological, psychological and behavioral disturbances induced by alcohol, to clarify relationships between reasons for drinking and problem drinking behavior, sobriety factors, neurobehavioral effects in alcoholics, etc. The following findings were obtained.
1.Factors affecting sobriety were examined by questionnaires among patients with alcohol dependency. A group of patients who had continued sobriety reported that they considered family, job and AA to be important.
2.Reasons for drinking in relation to problem drinking were studied in a group of high school students. Five factors of reasons for drinking, viz. escapism, sociability, tension-reduction, acting like a man and home/enjoyment, were identified. The first three were found to be related to problem drinking behavior.
3.Neurophysiological examinations were conducted on patients with alcohol dependency.The patients showed slowing of nerve conduction, changes in distribution of nerve conduction velocities and abnormal findings of ECG R-R interval variability.
Research findings have been published in journals and monograph and presented at scientific meetings.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Fujimura,Y.: "Assessment of the Distribution of Nerve Conduction in Alcoholics" Environmental Research. 61. 317-322 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Araki,S.: "Assessment of the Effects of Occupational and Environmental Factors on All Faster and Slower Large Myelinated Nerve Ftbers : A Study of the Distribution of Nerve Conduction Velocities" Environmental Research. 62. 325-333 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murata,K.: "Autonomic neurotoxicity of alcohol assessed by heart rata variability" Journal of the Autonomic Nervous System. 48. 105-111 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 森 宏明: "アルコール依存症者の断酒因子に関する疫学的研究" Jpn.J.Alcohol & Drug Dependence. 28(6). 453-466 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 横山 和仁: "飲酒動機が高校生の問題飲酒行動に及ぼす影響" 日衛誌. 51(1). 3-43 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fujimura, Y.: "Assessment of the Distribution of Nerve Conduction Velocities in Alcoholics" Environmental Research. 61. 317-322 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Araki, S.: "Assessment of the Effects of Occupational and Environmental Factors on All Faster and Slower Large Myelinated Nerve Fibers : A Study of the Distribution of Nerve Conduction Velocities" Environmental Research. 62. 325-332 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murata, K.: "Autonomic neurotoxicity of alcohol assessed by heart rate variability" Journal of the Autonomic Nervous System. 48. 105-111 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mori, H.: "Sobriety factors in alcoholics(in Japanese)" Jpn.J.Alcohol & Drug Dependence. 28(6). 453-466 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sata,F.: "Adjustnient of creati-nine-adjusted values in urine to urinaryflow rate:A study of eleven heavy metals and organic substances." International Archives of Occupational and Environmental Health. 68. 64-68 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Murata,K.: "Accumulation of VDT work-related visual fatigue assessed by visual evoked putential,near point distance and critical flicker fusion." Industrial Health. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokoyama,K.: "Anterior cerebellar lobe,spinocerebellar and bestibulocerebellar effects of n-hexane,toluene and xylene" American journal of Industrial Medicine. (submetted).

    • Related Report
      1995 Annual Research Report
  • [Publications] Fujimura,Y.: "Changes in the distribution of nerve conduction velocities in diabetics" Tohoke Journal of Experimental Medicine. (submitted).

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawakami,N.: "Effect of job stress on helper-inducer(CD4+CD29+)and suppressor-inducer(CD4+CD45RA+)T-cells in Japanese blue-collar workers." Psychosomatic Medicine. (submitted).

    • Related Report
      1995 Annual Research Report
  • [Publications] 横山和仁: "論説-産業医学領域における神経行動障害評価法の新しい展開を求めて" 産業衛生学雑誌. (印刷中).

    • Related Report
      1995 Annual Research Report
  • [Publications] 荒記俊一: "南山堂" 産業保健マニュアル(第3版). 179-180,△187-189 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 荒記俊一: "環境因子による非顕性の神経・精神行動障害の評価方法と最近の知見" 日本衛生学雑誌. 50. 713-729 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Araki,S.,: "Application of neurophysiological methods in Occupational in relation to psychological performance." Annals Academy of Medicine Singapore. 23. 710-718 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Murata,K.,: "Changes in autonmic function as determined by ECG R-Rinterval variabil in sandal.shoe,and leather workers exposed to n-hexane,xylene and tol" Neurotoxicology. 15. 867-876 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 横山 和仁: "断酒動機が断酒に及ぼす影響" 日本公衆衛生. (印刷中).

    • Related Report
      1994 Annual Research Report
  • [Publications] 森 宏明: "男子事務従事者の肝機能に及ぼす飲酒行動および生活習慣の影響" 衛生学雑誌. (印刷中).

    • Related Report
      1994 Annual Research Report
  • [Publications] Araki,S.,: "Neurobehavioral Methods and Effectsin Occupation and Enviraonmentul Health" Academic Press,USA, 1020 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 荒記 俊一: "最新内科学大系76 農薬中毒 E 臭化メチル中毒" 中山書店, 4 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 横山 和仁: "四エチール鉛中毒 新臨床内科 コンパクト版" 医学書院, 514 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 横山 和仁: "日本版POMS(Profile of Mood States)手引" 金子書房, 30 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kuboki,T.: "Multidimensional assessment of mental state in occupational health care." Environmental Research. 61. 285-298 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Murata,K.: "Autonomic neurotoxicity of alcohol assessed by heart rate variability" J.Autonomic Nervous System. (印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] 森宏明: "アルコール依存症者の断酒因子に関する疫学的研究" アルコール研究と薬物依存. 28. 453-466 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 横山和仁: "有機溶剤ニューロパオーの評価をめぐって" 末梢神経. 4. 61-67 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yokoyama,K.: "Proceedings of the ICPN" ICPN, 6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 横山和仁: "感情プロフィール検査(POMS)手引き" 金原出版(印刷中),

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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