Clinical significance of HCV infection in alcoholic liver disease
| Project/Area Number |
05670360
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
MONNA Takeyuki Osaka City University, Medical School, Professor, 医学部, 教授 (30046958)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Takashi Osaka City University, Medical School, Lecturer, 医学部, 講師 (30227144)
|
|---|
| Project Period (FY) |
1993 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | Alcoholic Liver Disease / HCV / HCV RNA |
|---|
| Research Abstract |
We studied hepatitis Cvirus (HCV) RNA among 143 subjects who had consumed at least 5 yr with liver diseases. The patients were classified into six groups by histological diagnosis as follows ; 7 patients with steatosis, 18 patients with fibrosis, 24 patients with alcoholic hepatitis, 39 patients with chronic hepatits, 42 patients with cirrhosis, and 13 patients with hepatocellular carcinoma.
The presence of HCV RNA was 0% in steatosis, 6% in fibrosis, 8% in alcoholic hepatitis, 69% in chronic hepatitis, 57% in cirrhosis, and 54% in hepatocellular carcinoma. The ALT concentration among the patients who stopped drinking without HCV RNA decreased more rapidly than those with HCV RNA.As regard for HCV genotype, the rate of HCV genotype 2 was high in the patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. In particular, all the patients with hepatocellular carcinoma had HCV genotype 2.
The results suggest that alcohol has some carcinogenetic actions among the patients with HCV genotype2.
|
Report
(4 results)
Research Products
(2 results)
