• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Outcome and treatments of children born to mothers with SLE

Research Project

Project/Area Number 05670431
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionJuntendo University School of Medicine

Principal Investigator

HASHIMOTO Hiroshi  Juntendo University School of Medicine, Rheumatology, Professor, 医学部, 教授 (60053120)

Co-Investigator(Kenkyū-buntansha) TSUDA Hiroshi  Juntendo University School of Medicine, Rheumatology, Assistant professor, 医学部, 講師 (60188555)
YOSHIDA Hiroyuki  Juntendo University School of Medicine, Gynecology, Assistant professor, 医学部, 講師 (90166950)
TAKASAKI Yoshinari  Juntendo University School of Medicine, Rheumatology, Associate Professor, 医学部, 助教授 (80154772)
古川 漸  山口大学, 医学部, 教授 (30095830)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
KeywordsSLE / Pregnancy / Spontaneous abortion / Neonatal lupus / Antiphospholipid / Anti SS-A / SS-B / Antinuclear factor / Plasmapheresis / HLA / neonatal LE / IgE / anti-cardiolipin / lupus anticoagulant / plasmapheresis / 全身性エリテマトーデス / 先天性房室ブロック / 習慣流産 / 抗SS-A抗体 / 抗SS-B抗体
Research Abstract

Spontaneous abortion was found in 11% and intrauterine death was found in 12% of 95 pregnancies of maternal SLE patients. Furthermore, growth retardation occurred in the immediate neonatal period. These risks were thought to associate with antiphospholipid antibodies including anticardiolipin antibodies and/or lupus anticoagulant. Four patients with neonatal lupus erythematosus including rash and congenital heart block and 32 patients with normal delivery were tested for antibodies against 60kD-SS-A, 52kD-SS-A and 48kD-SS-B antigens using immunoblotting. The frequencies of anti-52kD-SS-A and anti-48kD-SS-B antibodies were significantly higher than those in patients with normal delivery but not the frequency of anti-60kD-SS-A.The prevalence of allergic diseases including atopic dermatitis and bronchial asthma was higher in children of maternal SLE.Furthermore, 39% among 32 children had higher levels of serum IgE than those of normal range for age-matched healthy Japanese children. Eight out of twenty-twochildren more than 5 years old born to mothers with SLE had positive antinuclear antibodies. All of the maternal SLE patients whose children developed SLE had DQB1^*0601 of HLA class II alleles. Five pregnant SLE patients with antiphospholipid antibodies and four pregnant SLE patients with anti-52kD-SS-A and/or anti-48kD-SS-B antibodies were successfully treated with dextran sulfate plasmapheresis and double filtration plasmapheresis, respectively.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Matsuda Y.,et al.: "Therapeutic plasmapheresis for the treatment of pregnant SLE patients with antiphospholipid antibodies" Arthritis Rheum. 38. S392 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sasai K.,et al.: "Increased levels of serum IgE in children of mothers with SLE." Allergy. 50. 370-373 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hashimoto H.,et al: "HLA antigens in Japanese patients with systemic lupas erythematosus." Scand J Rheum. 23. 191-196 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本博史: "ハイリスク妊娠-22週までの管理-膠原病" 臨床婦産. 48. 890-891 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 橋本博史: "膠原病と先天異常" 産婦治療. 66. 33-37 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高崎芳成,他: "リウマチ'93(柏崎禎夫監修,新名,橋本編)" メディカルレビュー社, 129-135 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuda Y, et al: "Therapeutic plasmapheresis for the treatment of pregnant SLE patients with antiphospholipid antibodies." Arthritis Rheum. 38. S392 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sasai K, et al: "Increased levels of serum IgE in children of mothers with SLE." Allergy. 50. 370-373 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hashimoto H, et al: "HLA antigens in Japanese patients with SLE." Scand J Rheum. 23. 191-196 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hashimoto H, et al: "The effect of plasmapheresis in SLE patients with antiphospholipid antibodies." Therap Plasmapheresis. 12. 57-60 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsuda Y, et al.: "Therapeutic plasmapheresis for the trestment of pregnant SLE patients with antiphosphelipid antibodies" Arthritis Rheum. 38. S392 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sasai K, et al.: "Increased levels of serum IgE in children of mothers with SLE" Allergy. 50. 370-373 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hashimoto,H.,et al: "HLA antigens in Japanese patients with systemic lupus erythematosus." Scand.J.Rheum. 23. 191-196 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 橋本博史,他: "血漿交換療法の限界と将来" 神経治療学. 11. 445-448 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sasai,K.,et al.: "Increased levels of serum IgE in children of mothers with systemic lupus erythematousus." Eur.J.Allergy Clin Immunol. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Hashimoto,H,et al.: "The effect of plasmapheresis in systemic Iupus erythematosus patients with antiphospholipid antibodies." Therapeutic Plasmapheresis. 12. 57-60 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Dong,RP,et al.: "Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus." Tissue Antigen. 41. 20-25 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 橋本博史: "膠原病と先天異常" 産婦人科治療. 66. 33-37 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 橋本博史,他: "抗リン脂質抗体の基礎と臨床" リウマチ'93. 3. 10-25 (1993)

    • Related Report
      1993 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi