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Immunornodulatory effects of ursodeoxycholic acid

Research Project

Project/Area Number 05670491
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNara Medical university

Principal Investigator

TSUJII Tadasu  Nara Medical univ., Medicine, Professor, 医学部, 教授 (30075064)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Masahide  Nara Medical univ., Medicine, Research Associate, 医学部, 助手 (50230701)
ISHIZAKA Shigeaki  Nara Medical univ., Medicine, Associate Professor, 医学部, 助教授 (90159715)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsUrsodeoxycholic acid / Immunomodulatory effect / ウルソヂオキシコール酸 / 免疫調節作用 / 抗原提示
Research Abstract

We investigated the effects of ursodeoxycholic acid (UDCA) on antigen presentation using a mouse T cell hybridoma line as helper T cells and a mouse B cell lymphoma line as antigen presenting cells, both of which possessed defined antigen specificities. UDCA suppressed IL-2 production and cytotoxic activity of T cells. UDCA,however, did not reduce the spontaneous expression of either MHC class II molecules or antigen specific IgM on the surface of B cells. The capping and internalization of surface IgM during antigen exposure were not affected by UDCA.Furthermore, antigen-pulsed B cells in the presence of UDCA retained the ability of stimulating T cells. These results suggest that UDCA does not impair the function of antigen presenting cells and that UDCA may interfere with the recognition of processed antigen by T cells in antigen presentation.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Yoshikawa M,et al: "Effects of ursodeoxycholic acid on antigen presentation" International Hepatology Communication. 1. 243-249 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 吉川正英・辻井正: "原発性胆汁性肝硬変(PBC)におけるウルソデオキシコール酸の免疫調節作用" 医学のあゆみ. 172. 427-430 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 福井博他: "消化器病セミナー54 原発性胆汁性肝硬変・病態・治療・予後" ヘルス出版, 12 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻井正・吉川正英: "消化器病セミナー56 胆汁酸と消化器病-最近の進歩" ヘルス出版, 14 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshikawa M.et al: "Effects of ursodeoxycholic acid on antigen presentation" International Hepatology Communication. 1. 243-249 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshikawa M,Tsujii T: "Immunomodulatory effects of ursodeoxycholic acid on primary biliary cirrhosis" Journal of Clinical and Experimental Medicine. 172. 427-430 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Inoue K ed: Seminar of digestive diseases 54. Tokyo, Japan, Health Publication, 147-158 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Makino I ed: Seminar of digestive diseases 56. Tokyo, Japan, Health Publication, 1-14 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshikawa M,et al.: "Effects of ursodeoxycholic acid on antigen presentation" International Klepatology Communication. 1. 243-249 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 吉川正英・辻井正: "原発性胆汁性肝硬変(PBC)におけるウルデオキシコール酸の免疫調節作用" 医学のあゆみ. 172. 427-430 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 福井博 他: "消化器病セミナー54 原発性胆汁性肝硬変:病態・治療・予後" ヘルス出版, 12 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻井正・吉川正英: "消化器病セミナー56 胆汁酸と消化器病-最近の進歩" ヘルス出版, 14 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻井 正: "原発性胆汁性肝硬変の病態生理と治療" MB Gastro.3. 75-83 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshikawa,M.: "Effects of ursodeoxycholic acid on antigen presentation" Int.Hepatol.Commun.1. 243-249 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 〓川正英: "臨床胆汁酸研究の進歩" 医薬ジャーナル社, 90 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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