| Project/Area Number |
05670558
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
URAKAMI Katsuya (1995) Tottori University, Department of Neurology, Assistant Lecturer, 医学部, 講師 (30213507)
高橋 和郎 (1993-1994) 鳥取大学, 医学部, 教授 (10031965)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yoshiki Tottori University, Department of Neurology, Assistant Lecturer, 医学部・附属病院, 助手 (80243385)
浦上 克哉 鳥取大学, 医学部・附属病院, 助手 (30213507)
佐藤 建三 鳥取大学, 医学部, 助教授 (40113196)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Dementia of the Alzheimer type / Superoxide dismutase / Skin fibroblast / SOD / catalase / glutathion peroxidase / superoxide dismutase |
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| Research Abstract |
We examined superoxide dismutase (SOD) mRNA in skin fibroblasts with dementia of the Alzheimer type (DAT). THE DAT patients were divided into three subgroups as follows : Group A : patients that developed rapidly ; Group B : patients that developed gradually ; Group C : patients that developed very slowly. We determined SOD mRNA levels by Northern blot analysis. SOD mRNA level in skin fibroblast decreased in DAT, especially Group A.The change of SOD mRNA was closely correlate with clinical course of DAT.The determination of SOD mRNA in skin fibroblast may be useful for the diagnosis of three subgroups of DAT.
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