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Abnormality of free radical scavenging mechanism in skin fibroblasts with dementia of the Alzheimer type

Research Project

Project/Area Number 05670558
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTottori University

Principal Investigator

URAKAMI Katsuya (1995)  Tottori University, Department of Neurology, Assistant Lecturer, 医学部, 講師 (30213507)

高橋 和郎 (1993-1994)  鳥取大学, 医学部, 教授 (10031965)

Co-Investigator(Kenkyū-buntansha) ADACHI Yoshiki  Tottori University, Department of Neurology, Assistant Lecturer, 医学部・附属病院, 助手 (80243385)
浦上 克哉  鳥取大学, 医学部・附属病院, 助手 (30213507)
佐藤 建三  鳥取大学, 医学部, 助教授 (40113196)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
KeywordsDementia of the Alzheimer type / Superoxide dismutase / Skin fibroblast / SOD / catalase / glutathion peroxidase / superoxide dismutase
Research Abstract

We examined superoxide dismutase (SOD) mRNA in skin fibroblasts with dementia of the Alzheimer type (DAT). THE DAT patients were divided into three subgroups as follows : Group A : patients that developed rapidly ; Group B : patients that developed gradually ; Group C : patients that developed very slowly. We determined SOD mRNA levels by Northern blot analysis. SOD mRNA level in skin fibroblast decreased in DAT, especially Group A.The change of SOD mRNA was closely correlate with clinical course of DAT.The determination of SOD mRNA in skin fibroblast may be useful for the diagnosis of three subgroups of DAT.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 浦上克哉,他: "Alzheimer型痴呆患者皮膚線維芽細胞におけるlysosome機能には異常がない" 神経内科. 39. 650-652 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okada A et al: "Expression of amyloid beta-protein precursov mRNA in cultured slein fibroblasts taken from patieuts with demoatia" Demeutia. 5. 55-56 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 涌谷陽介他: "慢性関節リウマチを合併したアルツハイマー型老年痴呆症の2症例の検討" 神経内科. 43. 367-369 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Urakami K et al: "Amyloid beta protein precursor with kunitz-type protease inhibitor domains (APPI) in cerbrcspincl fluid and APPImRNAs in cultured skin fibroblasts of patieuts with Alzheimer" Tohoku J Exp Med. 174. 199-207 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Urakami K et al: "Cu, Zn superoxide dismutase in patieuts with demontia of the Alzheimer type" Acta Neurol Scand. 91. 165-168 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Waleutani Y et al: "Heat shcck protein 70mRNA levels in mononccelear blood cclls from patients with demcntia of the Alzheimer type" Dementia. 6. 301-305 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Urakami K,et al: "Characterization of the course of senile dementia of the Alzheimer type using cerebrospinal fluid levels of acetylcholinesterase and somatostatin" Acta Neurol Scand. 80. 232-237 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Urakami K,et al: "Cu, Zn superoxide dismutase in dementia of the Alzheimer type" Acta Neurol Scand. 91. 165-168 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 浦上克哉他: "Alzluimer型痴呆患者皮膚線維芽細胞におけうlysosome機能には異常がない" 神経内科. 39. 650-652 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okada A et al.: "Expression of amyloid beta-protein precursor mRNAs in cultured skin fibroblasts taken from patients with demeutia of Alzheimer type" Dementia. 5. 55-56 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Urakami K et al: "Amyloid beta protein precursor with leunitz-type protease inhibitor domain CAPPI1 in cerebrospinal fluid and APPI mRNAs in cultured skin fibroplast of patients" Tohoku J Exp Med. 174. 199-207 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 涌谷陽介他: "慢性関節リウマチを合併したアルツハイマー型老年痴呆症の2症例の検討" 神経内科. 43. 367-369 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Urakami K et al: "Cu Zu superoxide dismutase in patients with dementia of the Alzheimer type" Acta Neurol Scand. 91. 165-168 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Wakutani Y et al: "Heat shode protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the Alzheimer type." Dementia. 6. 301-305 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Urakami K: "Cu,Zn superoxide dismutuse in patients with dementia of the Alzheimes type." Acta Neurol Scond. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Urakami K: "Amyloid B protein precuvsor with kumitz-type protease inhibieor domims in CSF and APPI mRNAs in cultured skin fibroblasts of patients with Alzhesismeis dises." Tohoku J Exp Med. 174. 199-207 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Okada A: "Expression of amyloid beta-protein precursor mRNAs in cultured skin fibroblasts taken from patients with dementia of the Alzheimertype." Dementia. 5. 55-56 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shimomura T: "Platelet superoxide dismutase in migrane and Tension-type headache" Cephalalgia. 14. 215-218 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 浦上克哉: "アルツハイマー病におけるアミロイド前駆体蛋白の検討" 老年期痴呆研究会誌. 7. 117-122 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋和郎: "老年期痴呆の疫学" 循環. 148. 24-33 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 浦上克哉: "アルツハイマー型痴呆患者皮膚線維芽細胞におけるlysosome機能には異常がない。" 神経内科. 39. 650-652 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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