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Serum anti-phospholipid antibodies in patients with multiple sclerosis

Research Project

Project/Area Number 05670566
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionFukushima Medical College

Principal Investigator

YAMAMOTO Teiji  Fukushima Medical College, Dept.Neurology, Professor, 医学部, 教授 (10106487)

Co-Investigator(Kenkyū-buntansha) SAITO Tasuku  Fukushima Medical College, Dept.Neurology, Instructor, 医学部, 助手 (20215544)
TSUKAMOTO Tetsuro  Fukushima Medical College, Dept.Neurology, Associate Professor, 医学部, 助教授 (20171978)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsmultiple sclerosis / anti-phospholipid antibodies / 2-glycoprotein I
Research Abstract

We have measured serum antiphospholipid antibodies (aPL) in patients with multiple sclerosis (MS) using enzyme linked immunosorbent assey and examined the correlations between these antibodies and MS.This study included thirty-two patients with clinically definite MS,thirteen patients with other autoimmune neurological disease excluding collagen vascular diseases (disease control.A) , eight patients with collagen vascular diseases (disease control.B) and twenty-six healthy persons (normal control) . In MS group IgG antibody against cardiolipin (CL) was detected in 3 (9%) ; anti-CL antibody showed cofactor (2-glycoprotein I) dependency in 2 but one was cofactor independent. IgM antibody was elevated in 14 of 32 patients (449%) with MS,but cofactor dependency was not determined. However, this was significantly higer in frequecy than that of the disease control A (P<0.01) and normal control (P<0.01) . Each anti-CL IgG antibody purified from four patients had differed reactivities against DNA.In addition, the APLA positive group in MS possessed at higer rate of other autoantibodies such as antinuclear antibody than the negative group. However, clinically two groups of MS were indistinguishable. The higher incidence of APLA imply that a broad spectrum of autoantibodies might be produced in MS ; some antibodies presumably related directly to MS pathogenesis are yet to be identified but APLA might be one of those antibodies which are to be tested for the capability of central inflammation and demyelination.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] T.Sugiyama, T.Yamamoto: "SERUM ANTI-PHOSPHOLIPID ANTIBODIES IN PATIENTS WITH MULTIPLE SCLEROSIS" Tohoku J Exp Med.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sugiyama T.Yamamoto: "SERUM ANTI-PHOSPHOLIPID ANTIBODIES IN PATIENTS WITH MULTIPLE SCLEROSIS" Tohoku J Exp Medicine. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉山泰二 山本悌司: "抗リン脂質抗体と視神経疾患" 神経眼科. 11. 194-196 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 斉藤直史,山本悌司,他: "原発性抗リン脂質拡体症候群によるInpridsclerosisと多発性硬化症との異同が問題であって〓〓〓例." 神経外科. 39. 283-289 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本悌司: "モダンクリニカルポイント神経内科" 拡リン脂質拡体と神経疾患(分担)平山恵造編(金原出版), 230(50-51) (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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