| Project/Area Number |
05670599
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
MIWA Kunihisa Toyama Medical and Pharmaceutical Univ., School of Medicine, Assistant, 医学部, 助手 (70166221)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masatoshi College of Medical Technology, Kyoto University, Professor, 医療技術短期大学部, 教授 (50190046)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | low density lipoprotein / coronary artery spasm / variant angina / lipid peroxide / vitamin E / 高比重リポ蛋白 / 冠攣縮 |
|---|
| Research Abstract |
To elucidate whether oxidized low density lipoproteins related to the pathogenesis of coronary artery spasm, the sensitivity of plasma low density lipoprotein for Cu^<2+>-induced lipid peroxidation was examined in patients with variant angina. Significantly higher level of generation of thiobarbituric acid reactive substances from plasma low density lipoprotein after incubation with Cu^<2+> was seen in patients with active variant angina than those in patients with inactive variant angina, patients with organic coronary stenoses and control subjects. The vitamin E (alpha-tocopherol) content of low density lipoprotein in patients with active variant angina was significantly lower than those in others. These results indicate that vitamin E-deficient plasma low density lipoprotein in patients with active variant angina is highly susceptible to peroxidative modification.
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