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Basic and Clinical Research for Hepatitis C Virus Infection with Malignant Disease in Childhood

Research Project

Project/Area Number 05670687
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionYokohama City University

Principal Investigator

IKUTA Koichiro  Yokohama City University, School of Medicine, Assistant Professor, 医学部, 講師 (80159590)

Co-Investigator(Kenkyū-buntansha) MATSUYAMA Shusuke  Yokohama City University, School of Medicine, Professor, 医学部, 教授 (20045983)
SASAKI Hideki  Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (50106316)
SUMITA Hiroko  Yokohama City University, School of Medicine, Instructor, 医学部, 助手 (10254202)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsMalignant diseases / Hepatitis C / Liver Biopsy / IFN-therapy / RT-PCR / C型肝炎 / HCV-RNA / HCV subtype
Research Abstract

We evaluated the efficacy of interferon (IFN) therapy for ten cases with hepatitis C virus (HCV) infection, who had completely recovered from leukemia and other malignant diseases. The transaminase level was mildly elevated in eight cases, though remained normal in two cases. The pathological findings of liver biopsy before the IFN therapy showed persistent or aggressive chronic hepatitis in all cases. In four cases, HCV-RNA was continuously undetectable in the sera over one year after the cessation of IFN therapy. The pathological findings of the liver were remarkably improved in these cases. In three cases, disappearance of HCV-RNA was transient and the transaminase level was elevated again after the IFN therapy. No correlation was observed among the liver function, pathological finding, and the response to IFN.We concluded that the IFN therapy for the HCV infected children with malignancies was effective.

Report

(2 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] M.Tsukaada, A.Komiyama, S.Nakazawa, M.Tsuchida, H.Nishihira, T.Shitara, M.Ohira, Y.Tsunematsu, K.Yamamoto, Y.Hoshi, K.Yamada, R.Hosoya, T.Sato, F.Bessho, I.Tsukimoto, M.Yamamoto, K.Ikuta, T.Saito, K.Nishimura, and the Tokyo Children Cancer Study Group: "Treatment of standard risk acute lymphoblastic leukemia in children with the Tokyo Children Cancer Group (TCCSG) L84-11 protocol in Japan." International Journal of Hematology. 57. 1-7 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Sasaki, Y.Hirabayashi, T.Inoue, S.Taniguchi, K.Ikuta, S.Matuyama: "Promotion of survival and proliferation by interleukin-3, kit-ligand and erythropoietin on early and late appearing spleen colony forming units in culture." Stem Cells. 11. 555-561 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Ishida, J.Levin, G.Baker, PE.Stenberg, Y.Yamada, H.Sasaki, T.Inoue: "Biological and biochemical charecteristics of murine megakaryoblastic cell line L8057." Experimental Hematol. 21. 289-298 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Taniguchi, Y.Hirabayashi, T.Inoue, M.Kanisawa, H.Sasaki, K.Komatsu, KJ.Mori: "Hemopoietic stem-cell compartment of the SCID mouse : Double-exponential survive curve after gamma irradiation" Proc.Natl.Acad.Sci. USA. 90. 4354-4358 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Ikuta, K.Fujioka, H.Sumita, H.Takahashi, H.Sekigushi, S.Kai, Y.Kajigaya, T.Funabiki.H.Sasaki, S.Matsuyama: "High-Dose Busulfan, VP-16 and ACNU Therapy with Stem Cell Transplantation for the Treatment of Children with Acute Leukemia." Jpn.J.Clin.Hematol.34. 636-642 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Ikuta, K.Fujioka, H.Tkahashi, H.Sumita, H.Sekiguchi, N.Hanzawa, S.Kai, Y.Kajigaya, T.Funabiki.T.Okuyama, H.Sasaki, S.Matsuyama: "Treatment and Prognosis after Late Relapse in Childhood Acute Lymphoblastic Leukemia." Jpn.J.Clin.Hematol.34. 712-717 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Sasaki, K.Ikuta.T.Okuyama, T.Funabiki, Y.Kajigaya, S.Kai, H.Sekiguchi, N.Hanzawa, H.Sumita, H.Takahashi, K.Fujioka, M.Matsuda, S.Matsuyama: "The clinical course of acquired aplastic anemia in childhood ; a retrospective study" Int.J.Hematol. 60. 239-249 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Sasaki, Y.Hirabayashi, T.Ishibashi, T.Inoue, M.Matsuda, S.Kai, K.Ikuta, K.Yokoyama, T.Yokota, Y.Maruyama, S.Matsuyama: "Effects of erythropoietin, IL-3, IL-6, and LIF on a murine megakaryoblastic cell line : Growth enhancement and expression og receptor mRNAs." Leukemia Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Inoue, Y.Hirabayashi, H.Mitsui, H.Sasaki, E.P.Cronkite, J.E.Bullis, Jr, V.P.Bond, K.Yoshida: "Survival of spleen colony-forming units (CFU-S) of irradiated bonemarrow cells in mice : Evidence for the existance of a radio-resistant subfraction." Exp.Hematol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Inoue, Y.Hirabayashi, H.Sasaki, M.Matsuda, Y.Furuta, S.Aizawa: "Model of MDS-like myelodysplasia that transforms into single lineage-hemopoietic malignancies upon transplantation -Implication for pediatric myelodysplastic syndrome-" Int.J.Pedat.Oncol.Hematol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary

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Published: 1993-04-01   Modified: 2016-04-21  

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