| Project/Area Number |
05670687
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
IKUTA Koichiro Yokohama City University, School of Medicine, Assistant Professor, 医学部, 講師 (80159590)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Shusuke Yokohama City University, School of Medicine, Professor, 医学部, 教授 (20045983)
SASAKI Hideki Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (50106316)
SUMITA Hiroko Yokohama City University, School of Medicine, Instructor, 医学部, 助手 (10254202)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Malignant diseases / Hepatitis C / Liver Biopsy / IFN-therapy / RT-PCR / C型肝炎 / HCV-RNA / HCV subtype |
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| Research Abstract |
We evaluated the efficacy of interferon (IFN) therapy for ten cases with hepatitis C virus (HCV) infection, who had completely recovered from leukemia and other malignant diseases. The transaminase level was mildly elevated in eight cases, though remained normal in two cases. The pathological findings of liver biopsy before the IFN therapy showed persistent or aggressive chronic hepatitis in all cases. In four cases, HCV-RNA was continuously undetectable in the sera over one year after the cessation of IFN therapy. The pathological findings of the liver were remarkably improved in these cases. In three cases, disappearance of HCV-RNA was transient and the transaminase level was elevated again after the IFN therapy. No correlation was observed among the liver function, pathological finding, and the response to IFN.We concluded that the IFN therapy for the HCV infected children with malignancies was effective.
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