The roles of HLA genes relevant to gene therapy for human melanoma.
| Project/Area Number |
05670733
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MUTO Masahiko Yamaguchi Univ.Sch.Med., Dept.Dermat.Associate Professor, 医学部, 助教授 (40175625)
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| Co-Investigator(Kenkyū-buntansha) |
MOGAMI Satoshi Yamaguchi Univ.Sch.Med., Dept.Dermat.Assistant, 医学部, 助手 (30253149)
HAMAMOTO Yoshiaki Yamaguchi Univ.Sch.Med., Dept.Dermat.Lecturer, 医学部・附属病院, 講師 (90238080)
ASAGAMI Chidori Yamaguchi Univ.Sch.Med., Dept.Dermat.Professor, 医学部, 教授 (80035188)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Human melanoma / Disease susceptibility / HLA polymorphism / Gene therapy |
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| Research Abstract |
It has not been clear whether HLA antigens are associated with malignant melanoma in Japan. Acral lentiginous melanoma (ALM) may occur in Japanese but is uncommon in Caucasians. In order to elucidate involvement of HLA genes relevant to development of melanoma, we performed an HLA population survey, by using peripheral blood lymphocytes obtained from 58 unrelated Japanese patients with melanoma (20 nodular melanoma (NM) , 20 ALM,9 superficial spreading melanoma, 4 lentigo maligna melanoma, 4 melanoma derived from the membrane and 1 metastatic melanoma) . The results showed that there was a strong association between melanoma and HLA-B13 (p<0.0001) and Cw6 (p<0.03) . In NM,the frequency of HLA-B13 was extremely high. An increased frequency of HLA-B51 was seen in ALM (9/20=45 (%) vs 15/120=13 (%) in normal control) . In contrast, its frequency in NM was extremely decreased (1/20=5 (%) ) . HLA-B61 was decreased in a total of the melanomas. Thus, HLA-linked immune response or immune suppression gene (s) appear to contribute to the susceptibility to human melanoma. There might be genetic differences between NM and ALM.
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Report
(3 results)
Research Products
(7 results)
