| Project/Area Number |
05670764
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
ITOH Masamitsu UNIVERSITY OF TOKYO,DEPARTMENT OF RADIATION ONCOLOGY,ASSOCIATE, 医学部(医), 助手 (80176362)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Tokuko TOKYO UNIVERSITY OF FISHERIES,DEPARTMENT OF FISHERIES,PROFESSOR, 水産学部, 教授 (40092382)
SAKAI Kazuo UNIVERSITY OF TOKYO,DEPARTMENT OF RADIATION ONCOLOGY,LECTURER, 医学部, 講師 (40153837)
SASAKI Yasuhito UNIVERSITY OF TOKYO,DEPARTMENT OF RADIOLOGY,PROFESSOR, 医学部, 教授 (80081694)
SUZUKI Norio UNIVERSITY OF TOKYO,DEPARTMENT OF RADIATION ONCOLOGY,PROFESSOR, 医学部, 教授 (10010050)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | CANCER / RADIATION THERAPY / TUMOR BED / METABOLISM / BLOOD FLOW / ANGIOGENESIS / NMR / PHYSIOLOGICAL FACTORS / cancer / metabolic status / aerobic glycolysis / MRS |
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| Research Abstract |
Radiation therapy is becoming important from the point of view of local control on tumor and quality of life on patients. However, the biological background of radio-resistant regrowing tumor, especially physiological factors of irradiated bed is ever unknown. In this study, physiological factors on tumor bed in mouse tumor model have been investigated using P-31, H-2 NMR spectroscopy and p02. Low energy status, slow ATP synthesis, low pH and low p02 have been noted in tumor bed. In parallel, there are low density blood vessels in tumor bed and a large number of micro vessels, tortuous vessels have been shown in non-irradiated control group. In conclusion, low enegy status and low nutrition status on tumor bed may give an early effect to regrowing tumor by analysis of physiological factors but further investigation will be needed to elucidate the relationship between local control and physiological factors on radio-resistant regrowing tumor.
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