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A NEW APPROACH TO CT DIAGNOSIS WITH APPLICATION OF VASCULAR PERMEABILITY OF CONTRAST MEDIA - TISSUE CHARACTERIZATION BY USING PERFUSION IMAGE.

Research Project

Project/Area Number 05670779
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKOBE UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

SAKO Masao  KOBE UNIV., RADIOLOGY,ASSOC.PROF., 医学部・附属病院, 助教授 (60030970)

Co-Investigator(Kenkyū-buntansha) KUSUMOTO Masahiko  KOBE UNIV., RADIOLOGY,ASSIST.PROF., 医学部, 助手 (90252767)
HIROTA Shozo  KOBE UNIV., RADIOLOGY,ASSOC,PROF., 医学部・附属病院, 助教授 (20181216)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
KeywordsContrast media / Dynamic CT / Macromolecular contrast media / Perfusion image / Extravascular space / Iodinated starch / Subtraction image / CT / 血管透過性 / 高分子型造影剤
Research Abstract

A new approach to CT diagnosis for tissue characterization was experimentally studied by using two different molecular sized contrast media. The contrast media used were iopamidol (molecular weight 777) and iodoethylated starch (IES : molecular weight : 60,000) which was developed in our laboratory. Dynamic CT was performed on VX2 tumor of rabbit rabbit, implanted at the thigh. The first dynamic CT was done with iopamidol and after ascertaining that the tumor attenuation had returned to the pre-contrast level, the second dynamic CT was performed on the same slice with IES.The time-density curves obtained at the same areas on the images with each contrast agent were compared. Perfusion images were obtained with subtracting IES-image from iopamidol-image.
Histologic specimens obtained at the corresponding areas of images were examined comparing to the time-density curves and perfusion images. The attenuation difference between the two density curves was well correlated to tumor viability. we considered that iopamidol could rapidly permeate to extravascular space, while IES could not, staying mostly within the intravascular space. And thus, the attenuation difference between the two curves and perfusion images suggested to be an indicator of the dynamics of extravascular perfusion, providing a new information to CT diagnosis.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 佐古正雄: "非イオン性ダイマー型造影剤(lotrolan)の血管透過性及び血流動態に関する実験的検討" 日本医学放射線学会雑誌. 54. 32-39 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 佐古正雄: "CTによる造影剤の血管外腔拡散の評価と新しい診断法への可能性" 日本医学放射線医学雑誌. 54. 289-291 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 杉本幸司: "水溶性ヨード造影剤のdynamic CTにおける組織濃染度とその動態に関する実験的検討" 神戸大学医学部紀要. 54. 99-107 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 佐古正雄: "造影剤の血管透過性を応用する新しいCT診断法の開発-拡散画像による組織特性診断" インナービジョン. 9. 29- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 杉本幸司: "造影剤の血管透過性と拡散を応用する新しいCT診断法" 映像情報. 26. 919-925 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masao Sato: "Experimental study of contrast enhancement effect of iodinated contrast media on dynamic CT" Proc. of the 7th workshop of the German-Japanese radiological affiliation. 142-143 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masao Sako: "Experimental study on vascular permeability and hemodynamics of nonionic dimeric contrast media (Iotrolan) : A comparison to nonionic monomer on dynamic CT and angiography." NIPPON ACTA RADIOLOGICA. 54-1. 32-39 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masao Sako: "CT evaluation of extravascular perfusion of contrast medium and its potential to a new method of diagnosis : An experimental study using macro, micro-molecular contrast media." NIPPON ACTA RADIOLOGICA. 54-4. 289-291 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masao Sako: "A new approach to CT diagnosis with application of vascular permeability of contrast media -Tissue characaterization by using perfusion" INNERVISION. 9-7. 29 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Koji Sugimoto: "Experimental study of contrast enhancement effect of iodinated contrast media and the hemodynamics on dynamic CT - Comparative study of nonionic monomer and macromolecular agents on VX2 tumor of rabbit -" MEDICAL JOURNAL OF KOBE UNIVERSITY. 54-2・3・4. 99-107 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 佐古 正雄: "非イオン性ダイマー型造影剤(Iotrolan)の血管透過性及び血流動態に関する実験的検討" 日本医学放射線学会雑誌. 54. 32-39 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 佐古 正雄: "CTによる造影剤の血管外腔拡散の評価と新しい診断法の可能性" 日本医学放射線学会雑誌. 54. 289-291 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉本 幸司: "水溶性ヨード造影剤のdynamicCTにおける組織濃染度とその動態に関する実験的検討" 神戸大学医学部紀要. 54. 99-107 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 佐古 正雄: "造影剤の血管透過性を応用する新しいCT診断法の開発-拡散画像による組織特性診断" インナービジョン. 9. 29 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉本幸司: "造影剤の血管透過性と拡散を応用する新しいCT診断法" 映像情報. 26. 919-925 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Masao Sako: "Experimental study of contrast enhancement effect of iodinated contrast media on dynamic CT" Proc. of the 7th Workshop of the German-Japanese Rodiol. attiliation. 142-143 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 佐古正雄: "非イオン性ダイマー型造影剤(Iotrolan)の血管透過性及び血流動態に関する実験的検討-dynamic CT及び血管造影におけるモノマー型との比較-" 日本医学放射線学会雑誌. 54. 32-39 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐古正雄: "CTによる造影剤の血管外腔拡散の評価と新しい診断法への可能性-高分子及び低分子造影剤を用いた実験的研究-" 日本医学放射線学会雑誌. 54. 61-63 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉本幸司: "水溶性ヨード造影剤のdynamic CTにおける組織濃染度とその動態に関する実験的検討-非イオン性モノマー型と高分子型の分子サイズからみた比較検討-" 神戸大学医学部紀要. 54. 1-10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐古正雄: "造影剤の血管透過性を応用する新しいCT診断法の開発-拡散画像による組織特性診断" INNERVISION. 9. 29- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉本幸司: "造影剤の血管透過性と拡散を応用する新しいCT診断法" 映像情報. 26. 919-925 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐古正雄: "非イオン性ダイマー型造影剤(lotrolan)の血管透過性及び血流動態に関する実験的研究" 日本医学放射線学会雑誌. 54. 32-39 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐古正雄: "CTによる造影剤の血管外腔拡散の評価と新しい診断法への可能性" 日本医学放射線学会雑誌. (印刷中).

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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