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Regulatory mechanism of dopamine metabolism in rat brain.

Research Project

Project/Area Number 05670801
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

KURACHI Masayoshi  Toyama Medical and Pharmaceutical University Depart. of Neuropsychiatry, Prof., 医学部, 教授 (80019603)

Co-Investigator(Kenkyū-buntansha) SHIBATA Ryoko  Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 医学部, 助手 (40216023)
TANII Yasuyuki  Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 付属病院, 講師 (80227206)
SUZUKI Michio  Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 付属病院, 講師 (40236013)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Keywordsdopamine metabolism / entorhinal cortex / amygdala / schizophrenia / 側坐核 / デカン酸ハロペリドール / 前頭前野
Research Abstract

1.Changes in concentrations of dopamine (DA) and its metabolites (DOPAC and HVA) follwing haloperidol decanoate administration in rat were investigated. The results showed that the initial increase in HVA on day 1 had significantly attenuated as early as day 3 and diminished further on day 11 almost in parallel in the frontal cortex, caudate-putamen, and amygdala.
2.(1) Concentration of DA and its metabolites following the left entorhinal cortex lesion in rat brain were datermined and (2) The effects of acute administration of methamphetamine on DA release in the left amygdala in lesioned rats was measured by the in vivo microdialysis method. The results showed that (1) the only change on the 28th postoperative day was the increased concentration of DA in the lateral amygdala compared with the controls. (2) The DA release in the left amygdala in the lesioned rats was significantly higher than that in the controls. These results suggest that the entorhinal cortex lesioned rats may be useful for an animal model to study DA overactivity in schizophrenia.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Kurachi,M.Yasui,S.,Shibata,R.et al.: "Comparative study of dopamine metabolism with local cerebral glucose utilization in rat brain following the administration of haloperidol decanoate." Biol.Psychiatry,. 36. 110-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kurachi,M.,Shibata,R.,Murata,R.et al.: "Parallel development of dopamine metabolism tolerance in the rat prefrontal cortex,caudate-putamen and amygdala following haloperidol decanoate administration." Biol.Psychiatry,. 37. 487-490 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 倉知正佳: "精神分裂病研究のストラテジー." 精神医学,. 36. 615-619 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kurachi,M.,Aso,M.,Matsui,M.,et al. (ed.by Kato,N.): "Medial temporal lobe structures and schizophrenia. In : The Hippocampus : Functions and Clinical Relevance." Elsevier,Amsterdam,405-413 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Kurachi, R.Shibata, R.Murata, et al.: "Parallel development of dopamine metabolism tolerance in the rat pretrontal cortex, caudate-putamen and amygdala following haloperidol decanoate administration." Biol. Psychiatry. 37. 487-490 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Kurachi, M.Aso, M.Matsui, et al.: "Medial temporal lobe structures and schizophrenia." In : The Hippocampus : Functions and Clinical Relevance. (ed. by Kato, N.) Elsevier, Amsterdam. 405-413 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 倉知正佳: "定型的抗精神病薬" 精神医学. 36. 6-10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masayoshi Kurachi: "Parallel clevelopment of dopamine metabolism to lenance in the rat prefrontal cortex,caudate-putamen and amygdala" Biological Psychiatry. 37(in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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