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A Study on regional cerebral blood flow during contingent negative varidtion in Schizophrenics.

Research Project

Project/Area Number 05670803
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

JIBIKI Itsuki  Kanazawa University, Faculty of Medicine, Department of Neuropsychiatry, Associated Professor, 医学部・神経精神医学, 助教授 (60110532)

Co-Investigator(Kenkyū-buntansha) TSUJI Shirou  Hospital of Kanazawa University School of Medicine, Assistant, 医学部・付属病院・核医学, 助手 (70227388)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Keywordsregional cerebral blood flow / contingent negative variation / eventrelated potential / SPECT / Schizophrenic
Research Abstract

To study the generation mechanism of the contingent negative variation (CNV) , CNV and regional cerebral flow (rCBF) measured by SPECT were simultaneously recorded in 10 normal male subjects. Three days after or before the simultaneous recording, resting rCBF was measured. Both the early and late components of CNV were analyzed in 12 EEG recording sites. The relative rCBF values and absolute rCBF values were analyzed in 32 regions of interest (ROIs) . The rCBF during CNV recording showed no significant changes in any of ROIs compared with rCBF.However, the early CNV components in F4 significantly correlated with r CBF in right middle frontal gyrus and orbitofrontal cortex. And, the late CNV components in Cz and C3 significantly correlated with rCBF in the left thalamus. These results suggest that the frontal cortex and the left thalamus play an important in the generation of CNV.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Jibiki,I,et.al.: "Case Study of Monosymptomatic delusion of unpleasant body odor with Structural Frontal abnormaliry" Neuropsychobiology. 30. 7-10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Jibiki,I.et.al.: "Epilepsy and SPECT" Neuroscience and Biobehavioral Review. 18. 281-290 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Jibiki,I.et al.: "^<123>I-IMP SPECT brain imaging in epileptie psychosis:A study of two cases of temporal lobe epilepsy with schizophrenid-like syndrome" Neuro psycho biology. 28. 207-211 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Jibiki,I.et al.: "Quantitative assessment of regional cerebral blood flow with ^<123>I-IMP SPECT in normal adult subjects" Acta Neurologica. 15. 7-15 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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