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Circulating suppressing factor for muscarinic acetylcholine receptor in patients with senile dementia

Research Project

Project/Area Number 05670809
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Shigeto  Osaka University, Medical School Department of Geriatric Medicine Assistant professor, 医学部, 講師 (20150336)

Co-Investigator(Kenkyū-buntansha) FUKUO Keisuke  Osaka University, Medical School Department of Geriatric Medicine Lecturer, 医学部, 助手 (40156758)
井上 卓夫  大阪大学, 医学部附属病院, 医員
名畑 孝  大阪大学, 医学部附属病院, 医員
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsSenile dementia of Alzheimer type / Lysophosphatidylcholine / Albumin / ムスカリン性アセチルコリン / 血清 / 脂質 / リゾフォスファチジルコリン
Research Abstract

We evaluated the nature of circulating suppressing factors for muscarinic acetylcholine receptor (SFAMR) in patients with senile dementia of Alzheimer type (SDAT). SFAMR was evaluated in 48 patients with SDAT,in 17 patients with vascular type dementia (VD), in 5 patients with familial Alzheimer disease (FAD), 11 normal elderly controls (EC), and in 10 normal young controls (YC). SFAMR in YC was significantly lower then those in the other groups. SFAMR in SDAT was significantly greater than that in the EC,and that in FAD was much greater. SFAMR in VD was similar to that in EC.These observations suggest that SFAMR was increased in the senile groups and further increased in SDAT and FAD.After purification by CN column and HSG15S column, two peaks of SFAMR were detected with molecular weight of about 600 and 800. The former was coeluted with lysophosphatidylcholine. In vitro addition of lysophosphatidylcholine significantly suppressed the binding of [^3H] QNB to synaptosomal membranes, although lysophosphatidyl ethanolamine or lysophosphatidyl serine did not. Further addition of albumin almost completely blocked the suppressing effect of lysophosphatidylcholine. Moreover, serum levels of albumin was significantly lower in SDAT patients and FAD patients than those in other groups. These results indicate that lysophosphatidylcholine is one of factors causing SDAT through its suppressing effect on muscarinic acetylcholine receptor.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Chen Y,,Morimoto S.et al.: "Lysophosphatidy lcholine causes Ca^<2+>influx,enhanced DNA synthesis and cytotoxicity in caltured vascular smooth muscle cells" Atherosclerosis. 112. 69-76 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukuo S.,Morimoto S.et al.: "Elastase enhances CAMP accuwulation and the inhibition of DNA synthesis induced by op-41483.a stable prostacyclin analogue" Atherosclerosis. 110. 111-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koh H.,Morimoto S.et.al: "Effect of beraprost sodium,a stable analogue of prostacyetin,on hyperplasia,hypertrophy and glycosaminaglycon synthe" Artery. 20. 242-254 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koh H.,Morimoto S.et al: "Effect of angiotensin II receptor antagonist on angiotensin II-induced increases in cytosolic free calcium concentration" Journal of Cardiova scular Pharmacology. 23. 175-179 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitano S.,Morimoto S.et al.: "Recent Advances in Aging Science" Beregi E,GergelyIA.Rajezi K., 591-595 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukuo K.,Morimoto S.et al.: "Endothelium-derived factors and Vascular Function" Masaki T, 113-121 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen Y,Morimoto S,et al.: "Lysophosphatidylcholine causes Ca^<2+> influx, enhanced DNA synthesis and cytotoxicity in cultured vascular smooth muscle cells." Atherosclerosis. 112. 69-76 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukuo K,Morimoto S,et al.: "Elastase enhances CAMP accumulation and the inhibition of DNA synthesis induced by OP-41483, a stable prostacyclin analogue." Atherosclerosis. 110. 111-117 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koh H,Morimoto S,et al.: "Effect of beraprost sodium, a stable analogue of prostacyclin on hyperplasia, hyportorophy and glycosaminoglycan synthesis." Artery. 20. 242-254 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koh H,Morimoto S,et al.: "Effect of angiotensin II receptor antagonist on angiotensin II induced increases in cytosolic free calcium concentration" Journal of Cardiovascular Pharmacology. 23. 175-179 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitano S,Morimoto S,et al.: Recent Advance in Aging Science. 591-595 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukuo K,Morimoto S,et al.: Endothelium-derived Factors and Vascular Function.113-121 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen Y.Morimoto,S et al.: "Lysophosphatidylcholine causes Ca^<2+> influx,ewhanced DNA synthesis and cytotoxicity in cultured vascular smooth muscle cells." Atherosclerosis. 112. 69-76 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fukuo K,Morimoto S,et.al.: "Elastase enhances cAMP accunulation and the inhibition of DNA synthesis induced by OP-41483,a stable prostacyclin analogue." Atherosclerosis. 110. 111-117 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Koh H,Morimoto S,et al.: "Effect of beraprost sodium,a stable analogue of prostacyclin,on hyperplasia,hypertrophy and glycosaminoglycan synthlsin." Artery. 20. 242-254 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Koh H,Morimoto S,et al.: "Effect of angiotensin II receptor antagonist on angiotensin II-induced increases in cytosolic free calcium coucentration." Journal of Cardiouascular Pharmacology. 23. 175-179 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kitano,S Morimoto S et al.: "Recent Advances in Aging Science" Beregi E,Gergely IA,Rajczi K., PP591-595 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fukuo K,Morimoto S.et al: "Endothelium-derived Factors and Vascular Function" Masaki T, PP113-121 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 福尾恵介,森本茂人,他: "長寿症候群" 日本臨床. 別冊. 658-661 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 北野昇一,森本茂人,他: "Alzheimer病-Alzheimer型老年期痴呆とカルシウム代謝" Clinical Calcium. 3. 334-337 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森本茂人,他: "老年期痴呆とカルシウム代謝異常" 全薬JOURNAL. 150. 18-23 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森本茂人,他: "老年者へのアプローチ法" 現代医療. 25. 2151-2154 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 荻原俊男,森本茂人,他: "老年病-特集:内科最近の動き-" 内科. 71. 83-90 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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