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Disturbed brain areas in schizophrenia and their relationship to psychiatric symptoms.

Research Project

Project/Area Number 05670819
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

KISHIMOTO Hideji  Associate Professor Department of Psychiatry, Yokohama City University, 医学部・精神医学講座, 助教授 (60161444)

Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
KeywordsMRS / NAA / Cho (choline) / schizophrenia / psychiatric symptoms / blunted affect / delusion / hallucinations / choline / ポジトロンCT / 脳血流量
Research Abstract

Using PET tracer, the authors measured cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and glutamic acid pools in drug-naive chronic schizophrenic patients, and found decreased brain activity in the association areas of cortex. The CBF and CMRO2 were increased in the thalamus and the cingulate in drug-naive acute schizo-phrenic patients.
Concerning psychiatric symptoms in chronic schizophrenia, the hypoactivity in the frontal area was found in patients with symptoms of blunted affect and social withdrawal, whereas that in the parietal or temporal repion correlated with symptoms of delusion. However, hyperactivity was found in the thalamus and cingulate cortex in drug-naive acute schizophrenic patients with auditory hallucinations and excitability.
NAA (N-acetyl aspartic acid) and choline (Cho) were measured using proton MRS (magnetic resonance spectroscopy) in the frontal white matter region in drug-naive schizophrenic patients. NAA and Cho intensities were significantly decreased (p<0.001) in the frontal white matter region in drug-naive schizophrenic patients. NAA and Cho also showed positive correlations (p<0.025) in drug-naive schizophrenic patients whereas there was no correlation in normal controls. Reductions of the NAA and Cho concentrations in the frontal white matter in schizophrenic patients indicates a decrease in the neuronal network or the membrane alterations in schizophrenics.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Kishimoto, H: "Decreased brain N-acetyl-L-aspartic acid in drug-naive schizophrenic patients measured by using 1H-MRS." Psychiatry Research. 62. 306-312 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Brain imaging of affective disorders and schizophrenia." Psychiatrists. 1. 25-32 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Positron emmission tomography and affective disorders." Affective Disorders. 3. 99-112 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Computerized EEG and brain imaging studies in untreated schizophrenic patients-A report of seven cases-." J Psychiat Neurol. 47. 869-880 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岸本英爾: "ポジトロンCTによる脳障害部位と精神分裂病者の症状との関連(III)" 精神分裂病の生物学的研究. 5. 57-61 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岸本英爾: "精神分裂病の生物学的研究(I) ^1H-MRSによる薬物未投与精神分裂病者の脳代謝" 精神分裂病の生物学的研究. 6. 33-37 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岸本英爾,井村裕夫,芳賀達也: "レセプター -基礎と臨床-" 朝倉書店, 944 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岸本英爾,笠原喜,木村敏: "感情障害" 朝倉書店, 860 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Decreased brain N-acetyl-L-aspartic acid in drug-naive schizophrenic patients measured by using 1H-MRS" Psychiatry Research. 62 (in press). 306-312 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Brain imaging of affective disorders and schizophrenia" Psychiatrists. 1 (in press). 25-32 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Positron emmission tomography and affective disorders" Affective Disorders. 3. 99-112 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto, H: "Computerized EEG and brain imaging studies in untreated schizophrenic patients -A report of seven cases-" J Psychiat Neurol. 47. 869-880 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kishimoto,H.: "Decreased brain N-acety1-L-aspartic acid in drug-naive schizophrenic patients measured by using 1H-MRS." Psychiatric Research. 62. 306-312 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kishimoto,H.: "Brain imaging of affective disorders and schizophrenia." Psychiatrists. 1. 25-32 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kishimoto,H.: "Positron emmission tomography and affective disorders." Affective Disorders. 3. 99-112 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kishimoto,H.: "Computerized EEG and brain imaging studies in untreated schizophrenic patients-A report of seven cases-." J Psychiat Neurol. 47. 869-880 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岸本英爾: "ポジトロンCTによる脳障害部位と精神分裂病者の症状との関連(III)" 精神分裂病の生物学的研究. 5. 57-61 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岸本英爾: "精神分裂病の生物学的研究(I)IH-MRSによる薬物未投与精神分裂病者の脳代謝" 精神分裂病の生物学的研究. 6. 33-37 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岸本英爾: "レセプター -基礎と臨床-" 朝倉書店, 944 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岸本英爾: "感情障害" 朝倉書店, 860 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kishimoto,H.: "Positron emission tomography and affective disorders." Affective Disorders. 2. 99-112 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kishimoto,H.: "Amino acid pools,CBF and CMRO2 in affective disorders." Biological Psychiatry. 1. 91-93 (1991)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kishimoto,H.: "The new biological tool for diag & treatment in mental illness." Psychiatry. 2. 585-590 (1990)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kishimoto,H.: "The CBF and CMRO2 in drug-naive schizophrenia." Schizophrenia Research. 4. 414-415 (1991)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kishimoto,H.: "Schizophrenia and brain imaging." The Japanese Journal of Psychiatry and Neurology. 43. 715-716 (1989)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岸本,英爾: "精神分裂病-基礎と臨床-" 朝倉書店, 766 (1990)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岸本,英爾: "レセプター-基礎と臨床-" 朝倉書店, 944 (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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