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Epidemiologic and clinicopathologic study of presenile demented disorders

Research Project

Project/Area Number 05670820
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

ISEKI Eizo  Yokohama City University, Department of Psychiatry, Lecturer, 医学部, 講師 (30203061)

Co-Investigator(Kenkyū-buntansha) KOSAKA Kenji  Yokohama City University, Department of Psychiatry, Professor, 医学部, 教授 (60023800)
ODAWARA Toshinari  Yokohama City University, Department of Psychiatry, Assistiant, 医学部, 助手 (00244426)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
KeywordsPresenile onset / Demented disorders / Epidemiology / Clinicopathology
Research Abstract

In order to examine the demographic data of the patients with presenile dementia, the informations were obtained through questionnaires sent to 99 medical facilities, composed of 15 mental hospitals, and 96 hospitals and 88 clinics having Departments of psychiatry, neurology and neurosurgery. The objects were all the demented patients with the disease onset in the age of 30-64 years regardless of the cause. They had been the outpatients or inpatients during a month of Oct, 1995. The items of questionnaires were composed of sex, adress, age, duration, diagnosis, complications, severity and inheritance of dementia. As the result, the disorder of the highest incidence was Alzheimer's disease (AD), and the second was vascular dementia (VD). Other disorders included Pick's disease, progressive supranuclear palsy, alcholic dementia and brain injury, et al. Inheritance of dementia was found in 12% of the patients with AD.The patients with AD were usually severer than those with VD.The patients with alcohlic dementia had the high proportion of inpatients, although their severity of dementia was relatively mild. The epidemiologic study of presenile dementia is more difficult than that of senile dementia, because it includes various disorders, and has long duration of disease.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] E. Iseki et al.: "Evaluation of neuroparholegical stages based on quantifration of senile changes in-chemed eleindividuals and Alelever-type" Neuropathology. 13. 147-152 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 井関栄三ら: "びまん性レピ-小児病" Cteriahric Medicire. 32. 1437-1442 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Odanara et al: "Incidence and disribwion of sonile playnes and neuofihrillou targles in lase-onsar clitfuse Levy siderce disence" Newoptliology. 14. 7-11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 井関栄三ら: "精神科老人外来-現場からの報告と意見" 精神医学. 37. 833-836 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Odawara et al: "Investigtion of tan-2 positive minoglo-Hi cells in the sulurtul nuclin of huron neuvolejonerafive disorher" Neurosciene Letiers. 192. 145-148 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E. Iseki et al: "A pathological study of Lowy badies and senile changes in the orygdalu in diffue body disence" Neuroprology. 15. 112-116 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Kosaka & E.Iseki: "Levry body clementin" Cambridge University Press, 332 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iseki E,et al: "Evaluation of neuropathological stages based on quantification of senile changes in non-demented elderly individuals and Alzheimer-type dementia" Neuropathology. 13. 147-152 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iseki E,et al: "Diffuse Lewy body disease" Geriatric Medicine. 32. 1437-1442 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Odawara T, et al: "Incidence and distribution of senile plaques and neurofibrillary tangles in late-onset diffuse Lewy body disease" neuropathology. 14. 7-11 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iseki E,et al: "Psychogenic outpatient clinic ; a field report" Clinical Psychiatry. 37. 833-836 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Odawara T.et al: "Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerativ disorders" neuroscience Letters. 192. 145-148 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Iseki E,et al: "A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease" neuropathology. 15. 112-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka K & Iseki E: Lewy body dementia. Cambridge University Press, 332 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] E Iseki et al.: "Evaluation of neuropathological stages based on quontification of senies thanges in non-ilunted elunly individualy and alzleimer-type idemeria." Neuropathology. 13. 147-152 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 井関栄三: "びまん性レビー小体病" Cteriaric Medicine. 32. 1437-1442 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] T,Odawara et al.: "Incidence and dislvibuntion of sonib playes and reunfilivilleg targles in Lese-onser clitlnce levy body cliseal" Neunopatliogy. 14. 7-11 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 井関栄三: "精神竹老人外来-現場からの報告と発見" 精神医学. 37. 833-836 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T,Odawara et al.: "Investigation of tan-z positive ominogla-tile alls in the sufutral nucli of human newdylnerative disorderu" Neurosciene Letters. 192. 145-148 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E,Iseki,et al.: "A Pathological study of Lewy bodies and senile chrge in the amygdlu in cliffuen Lwy body disence" Neuropathology. 15. 112-116 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Kosaka& E,Iseki: "Lewy Body dementia" Cambride University Press, 332 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E,Iseki: "Evaluation of neuropatholozical stages based on quantification of senile changes in non-demented elderly individuals and Aleheimer-type dementia21GC01:Neuropethology" 13(印刷中). (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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