The regulation of gene expression for the genes associated with eosinophils.
| Project/Area Number |
05670927
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical School |
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Principal Investigator |
YAMAGUCHI Yuji Jichi Medical School, Lecturer, 医学部, 講師 (00220286)
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| Co-Investigator(Kenkyū-buntansha) |
KASAHARA Tadashi Jichi Medical School, Lecturer, 医学部, 助教授 (60049096)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | GATA-1 / eosinophil / Eosinophil peroxidase / Charcot-Leyden crystal / Transcription factor |
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| Research Abstract |
The analysis of the regulation of gene expression for the genes associated with eosinophils were caried out.
1.GATA-1 plays an important role in the eosinophil defferentiation of eosinophilic cell line, HL-60-C15 cells, and normal human bone marron cells.
2.In the promoter for the gene encoding human eosinophil peroxidase, a number of positively and negatively acting elements were identified.
3.The regulatory regions of Charcot-Leyden crystal protein were identified.
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Report
(3 results)
Research Products
(9 results)
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[Publications] Gomolin, H.I., Yamaguchi, Y., Palupillai, A.V., Dvorak, L.A., Ackerman, S.J., Tenen, D.G.: "Human eosinophil Charcot-Leyden crystal protein : Cloning and characterization of a lyso phospholipase gene promoter." Blood. 82. 1868-1874 (1993)
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., Ackerman, S.J.: "Expresion of mRNA for the GATA-binding proteins in human eosinophils and basophils : Potential role in gene transcription." Blood. 81. 3234-3241 (1993)
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Yamaguchi, Y., Zhang, D.E., Sun, Z., Albee, E.A., Nagata, S., Tenen, D.G., Ackerman, S.J.: "Functional characterization of the promoter for the gene encoding human eosinophil peroxidase." J.Biol.Chem.269. 19410-19419 (1994)
Description
「研究成果報告書概要(欧文)」より
Related Report
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