| Project/Area Number |
05670927
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical School |
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Principal Investigator |
YAMAGUCHI Yuji Jichi Medical School, Lecturer, 医学部, 講師 (00220286)
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| Co-Investigator(Kenkyū-buntansha) |
KASAHARA Tadashi Jichi Medical School, Lecturer, 医学部, 助教授 (60049096)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | GATA-1 / eosinophil / Eosinophil peroxidase / Charcot-Leyden crystal / Transcription factor |
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| Research Abstract |
The analysis of the regulation of gene expression for the genes associated with eosinophils were caried out.
1.GATA-1 plays an important role in the eosinophil defferentiation of eosinophilic cell line, HL-60-C15 cells, and normal human bone marron cells.
2.In the promoter for the gene encoding human eosinophil peroxidase, a number of positively and negatively acting elements were identified.
3.The regulatory regions of Charcot-Leyden crystal protein were identified.
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