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Study On The Role Of Growth Factors Factors For Growth Of Extremely Low Birth Weight Infants Using Extrauterine Fetal Incubation Model System Of Goats.

Research Project

Project/Area Number 05670973
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionKobe University

Principal Investigator

UETANI Yoshiyuki  School of Medicine, Kobe University Lecturer, 医学部, 講師 (40168620)

Co-Investigator(Kenkyū-buntansha) TAKADA Satoshi  School of Medicine Research Associate, 医学部, 助手 (10216658)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsextremely low birth weight infants / extrauterine fetal incubation / IGF-II / IGF-I / growth factor / fetal growth / lecithin / spingomyelin ratio / surfactant protein A
Research Abstract

To clarify the role of growth factors on growth of extremely low birth weight infants, plasma insulin like growth factor I and II (IGF-I,II) from the fetus of the goat incubated in extrauterine arterio-venous extracorporeal membrane oxygenation (A-V ECMO) system were determined by formic acid and acetone extraction method. IGF-I levels of the fetus were increased gradually after incubation, on the other hand, IGF-II levels were decreased to the mother's level within 60 to 80 hours after beggining of incubation. These results indicate that IGF-I plays an important role on growth of newborn infants and IGF-II on growth of fetus.
As the indicator of pulmonary surfactant synthesis, lecithin sphingomyelin ratio (L/S) and surfactant protein A (SP-A) levels in amniotic fluid or lung liquid were determined to evaluate the pulmonary maturation. 110-130 days of gestation, L/S ratios and SP-A of amniotic fluid were low, but those of lung liquid were increased rapidly after 60-70 hours after incubation.
Plasma IGF-II levels of human cord blood and extremely low birth weight infants were determined and compared at the same postconceptional weeks. IGF-II levels in cord blood were significantly higher than those of after birth. This difference is one of the cause of growth disturbance in extremely low birth weight infants compared to intrauterine growth.
These results indicate that induction of IGF-II will make it possible to establish the intrauterine growth in extremely low birth weight infants.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 久野克也: "ヤギ胎仔水中保育実験におけるドップラー超音波法を用いた血行動態の研究." 人工臓器. 22. 880-884 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 坂田雅宏: "Color Doppler法によるECMO A-VBypass下の山羊胎児血流分布の評価 -特に動脈管血流と胎児血行動態について-." 人工臓器. 23. 921-924 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hisano K,Okada M,Sakata M,Noma O,Yokoyama N,Uetani Y,Nakamura H: "Experimental study of artificial placenta ; Doppler echo cardiographic evaluation of goat fetal blood flow." Jpn J Artif Organs. 22 (3). 880-884 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sakata M,Hisano K,Okada M,Yasufuku M,Yokayama N,Uetani Y,Noma O,Nakamura H: "Experimental study of artificial placenta ; Doppler echocardiographic evaluation of goat fetal ductal blood velocity and waveforms in artificial placenta." Jpn J Artif Organs. 23 (3). 921-924 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 坂田雅宏: "Color Doppler法によるECMO A-V Bypass下の山羊胎児血流分布の評価-特に動脈管血流と胎児血行動態について-" 人工臓器. 23. 921-924 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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