| Project/Area Number |
05671014
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAKAMOTO Kiyoshi Medicine, Instructor, 医学部, 助手 (10162306)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Michio Medicine, Professor, 医学部, 教授 (30028691)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | trauma / soluble IL-6receptor / IL-6 / surgery / 可溶性IL-6レセプター / IL-6 |
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| Research Abstract |
IL-6 plays an important role in host defense following surgical trauma, especially in the production of acute phase reactants. IL-6 is induced unexceptionally after surgery and delivers the message into the target organ through its receptor. Recently, soluble IL-6 (sIL-6R) has been identified. However, alteration of sIL-6R and relation of IL-6 and sIL-6R after surgery are still unclear. In the present research, we investigated the postoperative change of IL-6 and sIL-6R and factors influencing their serum levels.Results were obtained as follows.
(1) The operation length, volume of blood loss during surgery, and thoracotomy are factors influencing the concentration of IL-6 in the blood. Re-elevation of serum IL-6 level is a sensitive marker of postoperative complications.
(2) IL-6 is produced and secreted in the operative field and subsequently enter the peripheral blood to induce cytokinemia.
(3) The serum sIL-6R concentration tended to decrease in the early phase of postoperative days and return to the postoperative level afterward, suggesting that there may be a mechanism of down-regulation of sIL-6R production or consumption of sIL-6R.We are now doing in vitro studies to clarify the mechanism.
(4) sIL-6R is not mainly produced in the postoperative field, which is different from IL-6.
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