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Long-term effects of small bowel transplantation on intestinal motility.

Research Project

Project/Area Number 05671035
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

KUSUNOKI Masato  Hyogo College of Medicine Research Associate, 医学部, 助手 (50192026)

Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsNANC / 小腸移植 / 外来神経 / 筋収縮
Research Abstract

We previously found that the contractile motility of the jejunum was increased 4 weeks after transplantation, and that dominant intrinsic neural component was changed from cholinergic to non-adrenergic, non-cholinergic (NANC). The present study investigated the long-term effects of transplantation on jejunal motility using rats that survived for 2 years postoperatively. Jejunal strips were harvested various group of rats, and intestinal motility was assessed by electrical transmural stimulation. Stimulation produced a similar increase of contraction at 4 weeks and 2 years after grafting. Pretreatment with atropine showed that the cholinergic component of contraction was respectively 45%, 24%, 32%, and 24% in adult controls, adult rats 4 weeks after transplantation, 2-year-old controls, and rats 2 years after transplantation. The NANC component (obtained with atropine and guanethidine) in each group was respectively 56%, 73%, 60%, and 69%. The actual valve of tetrodotoxin-insensitive myogenic component was significantly increased at 2 years after transplantation. These results suggested that the NANC component has a key role in the motility of transplanted small bowel throughout the life of the grafts.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] H.Ishii: "Enhancement on contraction of Rat jejunal Strips After Small Bowel Transplanation" Transplanation Proceedings. 26. 1655-1656 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Ishii: "CHANGES OF INTESTINAL MOTILITY AFTER SMALL BOWEL TRANSPLANTATION IN THE RAT" Transplanation. 57. 1149-1152 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Ishii, M.Kusunoki, T.Yamamura, and J.Utsunomiya: "Enhancement in Contraction of Rat Jejunal Strips After Small Bowel Transplantation."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Ishii, M.Kusunoki, S.Fujita, T.Yamamura, and J.Utsunomiya: "Changes of Intestinal Motility after Small Bowel Transplantation in the Rat."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Ishii: "Enhancement in Contraction of Rat jejunal Strips After Small Bowel Transplantation" Transplantation Proceedings. vol26,NO.3. 1655-1656 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Ishii: "CHANGES OF INTESTINAL MOTILITY AFTER SMALL BOWEL TRANSPLNTATION IN THE RAT" Transplanation. vol57,NO.8. 1149-1152 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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