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Basic and Clinical investigation for disordered defecation after low anterior resection

Research Project

Project/Area Number 05671073
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MIBU Ryuichi  Kyushu University, School of health sciences assistant professor, 医療技術短期大学部, 助教授 (20200107)

Co-Investigator(Kenkyū-buntansha) OHHATA Yoshihiro  Kyushu University, Faculty of Medicine, 医学部, 助手 (20253429)
岩本 拓也  九州大学, 医学部, 医員
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordscolon / rectum / motility / colectomy
Research Abstract

After anterior resection of the rectum (AR) with lymph node dissection, change in bowel habit is often observed even after recovery of the anorectal function possibly due to changes in colonic motility after the operation. This study was to investigate the relationship between the degrees of extrinsic autonomic nerve injury and the changes in colonic motility. [Methods] Twelve mongrel dogs were equally divided into four groups and underwent implantation of 5 serosal electrodes on the colon. Group A had denervation of autonomic nerves in the paraaortic and presacral regions, including hypogastric nerve and pelvic plexus, from the level of the axis of the caudal mesenteric artery (CMA) to the pelvic space. Group B had denervation in the paraaortic region from the axis of the CMA to the bifurcation of the iliac artery. Group C had denervation by dividing the mesocolon along the marginal artery from the CMA to the peritoneal reflection. Group D had only electrode implantation. Electromyogr … More aphic activity was measured continuously during 30 minutes in interdigestive state and 120 minutes after injection of olive oil through gastrostomy. The number of continuous electrical response activity (CERA) and contractile electrical complex (CEC) were counted in every ten minutes. [Results] Three weeks after the operation, colonic CERA and CEC in the period from 20 to 30 and 30 to 40 minutes after the olive oil injection was smaller (p<0.05) in Group A (2.2<plus-minus>0.72,3.4<plus-minus>1.12, respectively ; mean<plus-minus>SEM) than in Group D(10.6<plus-minus>1.97,10.8<plus-minus>2.24). This difference was present even in the right-sided colon (Group A : 0.4<plus-minus>0.28,0.6<plus-minus>0.40 ; Group D : 4.3<plus-minus>0.98,4.3<plus-minus>0.91 ; p<0.05). On the other hands, CERA and CEC in the interdigestive state in Group B (8.8<plus-minus>1.87)and C(7.6<plus-minus>1.45) were increased (p<0.05) as compared with Group D (5.2<plus-minus>0.83).Four months after the operation, increased colonic motility in Group B and C returned to the level of Group D,but the low colonic motility was still observed in the right-sided colon in Group A (0.8<plus-minus>3.32,0.4<plus-minus>3.32 ; p<0.05). [Conclusions] Pelvic plexus plays an important role in colonic motility even of the right-sided colon. The damage to theparasympathetic presynaptic neurons did not recover at least until 4 months after denervation. These data suggest that the pelvic plexus injury may cause the change in bowel habit after AR Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] M.Ishikawa,R.Mibu,T.Iwamoto,H.Konomi,M.Sakai,Y.Oohata,M.Tanaka: "Change in colonic motility after extrinsic auto nomic denervation in dogs" Gastw enterology. (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Ishikawa, R.Mibu, T.Iwamoto, H.Konomi, M.Sakai, Y.Oohata, M.Tanaka: "Change in colonic motility after extrinsic autonomic denervations in dogs." Gastroenterology. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M,Ishikawa,R,Mibu.T,Iwamoto et al.: "Change in colonic motility after extnirsie autonomic clenervation in dogs" Gartroenterology. (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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