| Project/Area Number |
05671088
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University School of Medicine |
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Principal Investigator |
YASUDA Seiei Tokai Univ.Surgical Dep.Assist.Prof., 医学部・外科, 講師 (10161861)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shin Tokai Univ, Radiol.Dep.Assist.Prof., 医学部・放射線科, 講師 (20131021)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | ^<99m>Tc-HMPAO / Leukocyte labelling / Leukocyte scan / Leukocytes / Neutrophils / SPECT / Inflammation / Infection / 膿瘍 / 画像診断 |
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| Research Abstract |
Leukocytes lavelled with technetium-99m haxamethylpropylene amineoxime (HMPAO) were used in 50 patients with known or suspected inflammatory or infectious focus. Forty milliliters of blood was obtained and labelled with Tc-99m. The labelling procedure was completed in 1 hour. Patients underwent imaging at 3 hours after the injection of labelled leukocytes. SPECT was performed in all patients. Analysis was made based upon SPECT images.
Of the 50 patients, focal desease was the final diagnosis in 24 cases. Tc-99m-labelled leukocytes showed 21 true-positive, 2 false-positive, 24 true-negative and 3 false-negative findings. Two parients with false-positive scan had intestinal obstruction, and faint bowel activity was visible. Three patients with false-negetive scan had liver abscess, and no increased activity was observed. The sensitivity of leukocyte scan was 87.5%, the specificity was 92.3%. It was concluded that SPECT images of Tc-99m leukocyte scan is useful in the diagnosis of inflammation or infection, except for liver abscess.
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