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Effect of environmental factors on risk of bowel cancer. ; agricultrual chemicals and colon cancer

Research Project

Project/Area Number 05671104
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

ITOH Hedeaki  UOEH,Professer, 医学部, 教授 (90038852)

Co-Investigator(Kenkyū-buntansha) HIRATA K  UOEH,Assistant, 医学部, 助手 (70269059)
KURODA Y  UOEH,Associate professor, 医学部, 助教授 (30131915)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsColon cancer / Experimental colon cancer / 1,2-Dimethyl hydrazine / Indomethacin / Epithelial cell proliferation / Herbicide / Trinitrobenzene sulfonic acid / Fibronectin / 1,2-dimethy1 hydrazine / 発癌プロモーター作用 / 2,4-Phenoxy acetic acid / Captan
Research Abstract

1) Experimental carcinogenesis in the rat intestine
Carcinogenesis in the rat intestine induced with 1,2-dimethylhydrazine (DMH), N-methyl-N-nitrosourea (MNU) was studied. The tumor frequently occurred in the intestinal tract extending from the duodenum to the colon in the DMH treated group. In the MNU treated group, the tumor occurred in the colon.
2) The effect of carcinogens on ornithine decarboxylase activity (ODC)
Tumor tissues in rat colon showed a high level of ODC activity compared wity the normal-appearing mucosa, and there was a correlation between tne level of ODC activity and histological grade of malignancy. ODC activity in the normal-appearing mucosa of the carcinogens-treated rat was significantly higher than that of control, and the number of tumors per rat was correlated with the level of ODC activity.
3) The effect of herbicides on the promoting activity in the intestinal carcinogenesis model of rats
3.1) 2,4-Phenoxy acetic acid (2,4-PA)
2,4-PA did not increase the incidenc … More e of tumors, nor cause a increase in BrdU labeling index of normal intestinal mucosa.
3.2) Captan
Captan increased the incidence of duodenal and colon tumors (no significance). It had no influence on the histological features, but increased the incidence of cancer metastasis to the lymph nodes and liver tumors. Captan treatment did not cause a increase in BrdU labeling index of normal intestinal mucosa.
4) Regression of rectal polyps by indomethacinn in familial adenomatous polyposis
The effect of indomethacin (IND) on rectal polyps was evaluated in patients with FAP.In addition, the effect of IND on rectal mucosal proliferation was assessed by immunostain using a monoclonal antibody to Ki-67 antigen. IND treatment was effective for the control of rectal polyps in FAP patients. However, IND treatment was not associated with a reduction in rectal cell proliferation.
5) The healing process of rat chronic colitis model.
The healing process of rat chronic colitis was investigated to evaluate the role of fibronectin produced by fibroblasts in the healing tissue. Observations elucidated the role of young fibroblasts, as multipotent cells, and the fibronectin in acceleration of the healing process of this model of chronic colitis. Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Hirata K,Itoh H,Ohsato K: "Regression of rectal polyps by indomethacin suppository in familial adomonatous polyposis." Diseases of the Colon and Rectum. 37. 943-946 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirata K,Itoh H,Nagata N,et al: "Experimental carcinogenesis in the rat intestine induced by two different carcinogens." Journal of UOEH. 16. 153-166 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirata K,Itoh H,Ohsato K ;: "Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis." Diseases of the Colon and Rectum. 37. 943-946 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirata K,Itoh H,Nagata N,et al: "Experimental carcinogenesis in the rat intestine induced by two different carcinogens." Journal of UOEH. 16. 153-166 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hirata K,Itoh H,Ohsato K.: "Reqression of rectal polyps by indomethacin suppository in familial adenomatous polyposis." Diseases of the Colon and Rectum. 37. 943-946 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirata K,Itoh H,Nagata N,et al.: "Experimental carcinogenesis in the rat intestine induced by two different carcinogens." Journal of UOEH. 16. 153-166 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirata K,Itoh H,Ohsato K.: "Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis." Diseases of the Colon and Rectum. 37(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hirata K,Itoh H,Nagata N,et al.: "Experimental carcinogenesis in the rat intestine induced by two different carcinogens." Journal of UOEH. 16(in press). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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