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Effects of endothelial cell growth factor on endotheliazation of small diameter vascular graft

Research Project

Project/Area Number 05671106
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

UCHIDA Naoki  Tohoku University, School of Medicine Assistant Proffesor, 医学部付属病院, 講師 (70241635)

Co-Investigator(Kenkyū-buntansha) TABAYASHI Koichi  Tohoku University, School of Medicine Proffesor, 医学部, 教授 (90142942)
毛利 平  東北大学, 医学部, 教授 (60108503)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsgrowth factor / endothelialization / small diameter vascular graft / chitosan / キトサン
Research Abstract

Purpose of this project is to evaluate in vivo effects of cell growth factor on endothelialization within a small diameter vascular graft. For this porpose a house-made vascular graft was fabricated. THe vascular graft was made of polyurethan and had two layrs, inner porous layr and puter solid layr. N-hexanoyl chitosan gel was inpregnated into these pores and smooth gel layr was formed inside the graft. Acid fobroblase growth factor was put into the gel layr. In vivo study using rabbits weighting 2.5 to 2.9 kg was failed because the arota was relatively small in diameter and tissue was fragile. Next step of this project will be focused on in vivo study using larger animal such as dogs.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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