| Project/Area Number |
05671126
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Sapporo Medical University School of Medicine |
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Principal Investigator |
KAZUI Teruhisa Sapporo Medical University School of Medicine, Second Department of Surgery, Assistant Professor, 医学部, 講師 (20094203)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshiaki Sapporo Medical University School of Medicine, Second Department of Surgery Inst, 医学部, 助手 (20188311)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Aortric Arch Aneurysm / Cerebral Protection / Retrograde Cerebral Perfusion / Selective Cerebral Perfusion / Hypothermic Circulatory Arrest / Somatosensory Evoked Potential / 弓部大動脈瘤 / 脳保護 / 逆行性脳濯流法 / 選択的脳濯流法 |
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| Research Abstract |
Retrograde cerebral perfusion (RCP), selective cerebral perfusion (SCP) and hypothermic circulatory arrest (HCA) were compared in terms of their effect on cerebral fumction of dogs as evaluated by somatosensory evoked potentials (SEP). Nineteen mongrel dogs were divided into three groups and subjected to RCP (n=8), SCP (n=6) and HCA (n=5) for 90 minutes. Brain temperatures were held at 20ﾟC and then rewarmed gradually to normal temperature. SEP completely disappeared as soon as RCP or HCA started and never recovered except one case in the HCA group. However SEP reappeared in five cases out of eight in the RCP group, the amplitude was below 50% of normal. In the SCP group, it recovered in all cases. Only 2% of cerebral blood flow (CBF) and about 3% of cerebral metabolic rate for oxygen (CMR02) were obtained during RCP compared to pre-operation value. The analysis of cerebral tissue ATP and water content supported these results. RCP had some advantage for cerebral protection compared with HCA,but could not supply sufficient CBF to maintain brain function. SCP was the safest method in arch reconstruction that requires cerebral protection for 90 minutes.
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