| Project/Area Number |
05671137
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
IMAI Yasuharu Tokyo Women's Medical College, Faculty of Medicine, Professor, 医学部, 教授 (30075246)
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| Co-Investigator(Kenkyū-buntansha) |
BEPPU Toshiyuki Tokyo Women's Medical College, Faculty of Medicine, Research Fellow, 医学部, 助手 (30181481)
HIGASHIDATE Masafumi Tokyo Women's Medical College, Faculty of Medicine, Research Fellow, 医学部, 助手 (90138917)
HOSHINO Shuichi Tokyo Women's Medical College, Faculty of Medicine, Assistant Professor, 医学部, 講師 (80120046)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | cardiopulmonary bypass / assisted circulation / centrifugal pump / computer control / microcomputer / automatic control |
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| Research Abstract |
A pump control system for a cardiopulmonary bypass is developed utilizing a microcomputer. The parameters monitored by the computer are central venous pressure, aortic pressure, blood volume in a reservoir, and collapsing of a small vinyl bag in a venous withdrawal tube. Both pumps in the arterial infusion and the venous withdrawal line are automatically controlled through an interface unit throughout cardiopulmonary bypass. The system regulates central venous pressure with a proportional-integral control algorithm to maintain intravascular volume constant. A screening algorithm is devised to remove artifacts introduced to the pressure measurement. At the weaning period, a perfusionist can select either the central venous pressure control, or a reservoir blood volume control. Computerized pump-purfusion was applied on 100 children cases during open heart surgery, where perfusion flow and central venous pressure were controlled satisfactorily with stable operation. Compared with conventional manually controlled pump-perfusion, no significant difference was noted in mean aortic pressure and central venous pressure, net fluid balance, total urination, blood chemistry, and urinalysis. This system is useful and is expected to improve the safety of pump-perfusion.
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