| Project/Area Number |
05671145
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HYODO Akio University of Tsukuba, Dept of Neurosurgery, Assistant Professor, 臨床医学系, 講師 (40167606)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Shinichi National Institute of Bioscience and Human Technology, 生命工学工業技術研究所, 次長
NOSE Tadao University of Tsukuba, Dept of Neurosurgery, Professor, 臨床医学系, 教授 (10009699)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | intravascular neurosurgery / interventional neuroradiology / embolic material / thermosensitive polymer / embolization / acute toxity / N-isopropylacrylamide / N-n-propylacrylamide |
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| Research Abstract |
Application of thermosensitive polymers to an embolic material for intravascular neurosurgery was investigated. A copolymer of N-isopropylacrylamide (NIPAM) and N-n-propylacrylamide (NPAM) is a kind of thermosensitive polymer. It is soluble in water below its transition temperature (TT), but insoluble beyond this temperature. The advantage of this copolymer is that TT can be controlled by changing the ratio of monomers.
We intended to use the thermosensitive polymer to occlude vessels by precipitation in responce to body temperature. Todetermine the optimal TT for the embolic material, an in vitro flow model was developed. From this study th copolymers with a TT of 24ﾟC-26ﾟC showed appropriate precipitation. To prove the occlusion of vessels in vivo, we injected into a kidney of a rabbit through a microcatheter. The embolization was identified by angiography and histological examination. And this copolymer showed no acute toxcity in mice.
This polymer has many advantages as an embolic material ; i.e.it is water soluble, no adhesive, and non toxic.n addition, various embolic materials can be desighned by changing the TT.Based on our results, we believe that the application of thermosensitive polymers as a new embolic material is very promising.
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