Mechanism of Rupture of the Cerebral Aneurysm in Relation to Degeneration of Vascular Smooth Muscle Cells.
Grant-in-Aid for General Scientific Research (C)
|Allocation Type||Single-year Grants |
|Research Institution||Kinki University (1994)|
Osaka University (1993)
TANEDA Mamoru Kinki University School of Medicine, Professor, 医学部, 教授 (10236713)
KATAOKA Kazuo Kinki University School of Medicine, Associate Professor, 医学部, 講師 (10221178)
YAMADA Kazuo Nagoya City University Medical School, Professor, 医学部, 教授 (90150341)
早川 徹 大阪大学, 医学部, 教授 (20135700)
大槻 秀夫 大阪大学, 医学部, 助手 (50240841)
|Project Period (FY)
1993 – 1994
Completed (Fiscal Year 1994)
|Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
|Keywords||Cerebral aneurysm / Subarachnoid hemorrhage / Vascular smooth muscle cell / Vascular endothelial cell / ruptured aneurysm / unruptured aneurysm / incidental aneurysm / smooth muscle / smooth muscle actin / fibroblast growth Factor(FGF) / aneurysmal pathology / degeneration|
Purpose : It is useful to know the pathophysiology of the incidental cerebral aneurysms for the decision of the surgical indication of the incidental cerebral aneurysm.
Methods : The aneurysmal sacs were collected at the time of clipping of aneurysm and from the autopsy. We immunohistochemically evaluated the wall of the cerebral aneurysm using anti-sooth muscle actin antibody.
Using the scanning electron microscopy, we compared the vascular endothelial cell layr of the incidental aneurysm and that of the reptured aneurysm.
We analyzed the mechanism of the growth and rupture of the incidental aneurysm associated with carotid occlusion.
At the time of the surgical exposure of the aneurysms at the internal carotid artery and the posterior communicating artery, we analyzed the relationship between the oculomotor nerve and the aneurysmal sac.
Results : In the pathological study, there was a marked difference between ruptured and incidental aneurysms in the aneurysmal walls stained immunohistoch
emically with anti-smooth muscle actin antibody. Smooth muscle cells were scanty in the ruptured aneurysms. In the incidental aneurysms, a layr of smooth muscle cells was clearly observed.
Inside of the sac of the ruptured aneurysm, there were various destructive changes of the endothelial cell layr. Contrary, clear endothelial cell layr covered inside of the incidental aneurysmal sac.
In the analysis of the incidental aneurysm associated with carotid occlusion, the hemodynamic stress caused by carotid occlusion plays an important role in the growth and rupture of aneurysm.
In the aneurysm at the internal carotid artery and the posterior communicating artery, the simple compression to the oculomotor nerve did not cause the nerve palsy. In the case of the oculomotor palsy associated with the internal carotid artery aneurysm, there was severe adhesion between the nerve and the aneurysmal sac.
Conclusion ; Present study morphologically revealed characteristic differences between the incidental aneurysms and the ruptured aneurysms. Less
Report (3 results)
Research Products (29 results)