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Embryopathegenesis of cerebral dysgenesis and involvement of NGF in the neuronal maturation

Research Project

Project/Area Number 05671187
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionTokai University School of Medicine

Principal Investigator

OI Shizuo  Tokai Univ.Sch.of Med., Neurosurgery, Assoc.Prof., 医学部・脳神経外科, 助教授 (30194062)

Co-Investigator(Kenkyū-buntansha) HONDA Yumie  Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (40266416)
HIDAKA Mitsugu  Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (90256123)
TANAKA Yoshimi  Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (20227193)
TAKEI Futoshi  Tokai Univ.Sch.of Med., Neurosurgery, Assist.Prof., 医学部・脳神経外科, 講師 (00216839)
SATO Osamu  Tokai Univ.Sch.of Med., Neurosurgery, Professor, 医学部・脳神経外科, 教授 (00023763)
継 淳  東海大学, 医学部・脳神経外科, 助手 (30266415)
下田 雅美  東海大学, 医学部・脳神経外科, 講師 (10206237)
松前 光紀  東海大学, 医学部・脳神経外科, 講師 (20209604)
小田 真理  東海大学, 医学部・脳神経外科, 助手 (10246118)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsNerve Growth Factor (NGF) / Fibroblastic Growth Factor (FGF) / Cholinergic Neuron / Neuronal Maturation / Dysraphic State / Spina Bifida / Experimental Mouse Model / Hippocampus
Research Abstract

The embryopathegenesis of dysraphic state has been extensive investigated in our previous laboratory experiments. The most striking findings revealed in the animal models of dysraphism, especially in "chick embryo myeloschisis or exencephaly models were the overmaturation of the neural placode. We have proposed a new hypothesis of pathogenesis of dysraphic state, namely "Overgrowth & Reopening" therapy.
The purpose of the research project in this period is to analyze the developmental process of nerve growth factor (NGF) along with the disturbed neuronal maturation process with "overgrowth" . The immunohistochemical technique was applied in the normal mouse and exencephalic mouse model. One of the NGF family (fibroblast growth factor : basic FGF) appeared in the hippocampus immediately after birth (This period is in the third trimester of the fetal life in human. The further investigation is now ongoing to compare the data from the dysraphic models.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Oi Sizuo: "Neuronal overmaturation in dysraphism : ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in evencephaly" Child,s Nevoous System. 11-9. 504-510 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大井静雄: "Neuro-Vascular Developmental Intreraction:胎生期の脳血管発生の特殊性(Part-2)胎児の脳血管障害の特殊性(臨床例の分析)" 脳神経外科ジャーナル. 投稿中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大井静雄: "胎生期の脳血管発生の特殊性と脳循環の発達" 神経研究の進歩. 40(印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shizuo Oi: "Neuronal overmaturation in dysraphism : ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in evencephaly." Child's Nervous System. 11-9. 504-510 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shizuo Oi: "Neuro-Vascular Developmental Interaction ; Specific Form of Vascular Maldevelopment in Malformed Brain. (Part-2) Cerebrovascular Diseases in Fetus : Analysis of Clinical Cases." Noshinkeigeka Journal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shizuo Oi: "Characteristics of intracranial vascular development in fetus and maturation of cerebral hemodynamics." Advances in Neurological Sciences. 40 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Oi Shizuo: "Neuronal overmaturation in dysraphism: ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in evencephaly" Child's Nervous System. 11-9. 504-510 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大井静雄: "Neuro-Vascular Developmental Intreraction:胎生期の脳血管発生の特殊性(Part-2)胎児の脳血管傷害の特殊性(臨床例の分析)" 脳神経外科ジャーナル. (投稿中).

    • Related Report
      1995 Annual Research Report
  • [Publications] 大井静雄: "胎生期の脳血管発生の特殊性と脳循環の発達" 神経研究の進歩. 40(印刷中). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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