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Studies on the mechanism of osteopenia associated with abnormal endocrine conditions

Research Project

Project/Area Number 05671220
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HOTOKEBUCHI Takao  Kyusyu University, Faculty of Medicine, Assistant Professor., 医学部, 講師 (40190219)

Co-Investigator(Kenkyū-buntansha) JINGUSHI Seiya  Kyusyu University, Faculty of Medicine, Research Associate., 医学部, 助手 (80235829)
IZUMI Toshihiro  Kyusyu University, Faculty of Medicine, Research Associate., 医学部, 助手 (90253426)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsEndocrine abnormality / Growth hormone / Growth factor / Thyroid hormone / Fracture / 骨粗鬆症 / ホルモン / 遺伝子発現
Research Abstract

We studied the relationship between a systemic factor, growth hormone, and local peptide growth factors in the skeletal system in normal rats. Human recombinant growth hormone was injected subcutaneously in 4-week-old rats, and sequential changes of serum growth hormone and gene expression of growth factors were analyzed. Serum growth hormone showed a peak 6 hours after the initial injection. Systemic administration of growth hormone slightly decreased mRNA for transforming growth factor-beta (TGF-beta) in femoral bones 6 hours after the initial injection, but the mRNA returned to the initial level 12 hours after the initial injection. However, there was no statistical significance. On the other hand, mRNAs for basic fibroblast growth factor (bFGF) and insulin-like growth factor-I (IGF-I) increased in response to growth hormone in costal cartilage. These data suggest that local peptide growth factors are regulated by systemic growth hormone.13EA02 : In the second part of our study, fracture healing in the drug-induced hypothyroid rats was studied. The fracture callus had lower torsional stiffness in hypothyroid rats in mechanical testing. Depletion of thyroid hormone also suppressed chondrogenesis and endochondral ossification. Northern analysis revealed decreased expression of alkaline phosphatase and osteocalcin, which are the indices for bone formation. These data suggest the suppressed bone formation in the hypothyroid condition.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Izumi,T.: "Growth hormone modulated the gene expression of growth factors in rat cosatal cartilage in vivo." Orthop.Trans.18. 458-459 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shida,J.: "A single injection of basic FGF stimulates articular cartilage enlargement in rat knee joints." Orthop.Trans.18. 461- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jingushi,S.: "A combination treatment with basic fibroblast growth factor and perichondrium autograft for a full-thickness articular cartilage defect." Orthop.Trans.18. 461-462 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iwaki,A.: "Localization and quantification of proliferating cells during rat fracture repair." Orthop.Trans.18. 511- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 神宮司誠也: "Basic fibroblast growth factor及びTransforming growth factorβの骨折治癒過程における細胞増殖制御への関与." 骨折. 16. 5-8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Izumi, T.: "Growth hormone modulated the gene expression of growth factors in rat cosatal cartilage in vivo." Orthop.Trans.18. 458-459 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jingushi, S.: "A combination treatment with basic fibroblast growth factor and perichondrium autograft for a full-thickness articular cartilage defect." Orthop.Trans.18. 461-462 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shida, J.: "A single injection of basic FGF stimulates articular cartilage enlargement in rat knee joints." Orthop.Trans.18. 461 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iwaki, A.: "Localization and quantification of proliferating cells during rat fracture repair." Orthop.Trans.18. 511 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jingushi, S.: "Involvement of basic fibroblast growth factor and transforming growth factor beta for cell proliferation during rat fracture repair. (in Japanese)" Kossetsu. 16. 5-8 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Izumi,T.: "Growth hormone modulated the gene expression of growth factors in rat cosatal cartilage in vivo." Orthop.Trans.18. 458-459 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shida,J.: "A single injection of basic FGF stimulates articular cartilage enlargement in rat knee joints." Orthop.Trans.18. 461 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Jigushi,S.: "A combination treatment with basic fibroblast growth factor and perichondrium autograft for a full-thickness articular cartilage defect." Orthop.Trans.18. 461-462 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Iwaki,A.: "Localization and quantification of proliferating cells during rat fracture repair." Orthop.Trans.18. 511 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 神宮司誠也: "Basic fibroblast growth factor及びTransforming growth factorβの骨折治癒過程における細胞増殖制御への関与." 骨折. 16. 5-8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Izumi: "Growth hormone modulated the gene expression of growth factors in rat costal cartilage in vivo" Orthopedic Transaction. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Urabe: "Thyroid hormone regulates matrix formation and expression of mineralization-associated genes by osteoblasts21GC02:Orthopedic Transaction" (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.jingushi: "A combination treatment with basic fibroblast growth factor and perichondrium autograft for a full-thickness articular cartilage defect" Orthopedic Transaction. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] J.Shida: "A single injection of basic FGF stimulates aricular cartilage enlargement in rat knee joints" Orthopedic Transaction. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Iwaki: "Localization and quantification of proliferating cells during rat fracture repair" Orthopedic Transaction. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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