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Immunity to type II collagen and proteoglycan in OA.

Research Project

Project/Area Number 05671229
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKitasato University

Principal Investigator

TAKAGISHI Kenji  Kitasato Univ.Orthop.Surg.Professor, 医学部, 教授 (70154763)

Co-Investigator(Kenkyū-buntansha) TONEGAWA Masatoshi  Kitasato Univ.Orthop.Surg.Instructor, 医学部, 助手 (40217518)
NISHIMURA Akito  Kitasato Univ.Orthop.Surg.Instructor, 医学部, 助手 (70208213)
GOSO Yukinobu  Kitasato Univ.Biochem.Assistant Professor, 医学部, 講師 (20112659)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsOsteoarthritis / Type II collagen / Proteoglycan / Mice / Immunity / Human / Rheumatoid arthritis / 免疫反応 / プロテオグリカン
Research Abstract

We measured immunity to type II collagenand proteoglycans in osteoarthritic C57BL mice to determine whether it is related to osteoarthritis pathogenesis. Histological examination revealed articular cartilage lesions in all mice and synovitis in only a few mice. Immunological responses to type IIcollagen were found in collagen arthritic mice, but not in C57BL mice. Furthermore, immunological responses to proteoglycans were observed in proteoglycanimmunized mice, but not in C57BL mice Therefore, articular cartilage degeneration may not result in autoimmunity to type II collagen and proteoglycans in osteoarthrits of C57BL mice, and immune responses to these We also measured the serum anti-type II collagen antibody in osteoarthritic patients. No humoral immunity was revealed in healthy people and definete anti-type II collagen antibody was showed in several patients with rheumatoid arthritis. In one of fifty osteoarthritic patients, the humoral immunity to type II collagen was revealed. In human osteoarthritis. Immunity to type II collagen might be related to the pathogenesis of the disease in a certain patient.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Takagishi K.: "Effects of Cyclosporin on serun hyaluranate levelsin collagen arthritis" Inflammation Research. 44. 79-82 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagishi K.: "Absence of Immunity to type II collagen and proteoglycan in osteoarthritic C57 Black mice" Inflammation Research. 44. 222-226 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagishi K., Itoman M,Goso Y., Kuwao S., Miyahara H., Kaibara N.: "Effects of cyclosporin on serum hyaluronan levels in collagen arthritis." Inflammation Research. 44. 79-82 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagishi K., Maeda K., Goso Y., Itoman M,Yamamoto M.: "Absence of immunity tu type II collagen and proteoglycan in osteoarthritic C57BL mice." Inflammation Research. 44. 222-226 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takagishi K.et al: "Effects of cyclosporin on serum hyaluronan levels in collagen arthritis" Inflammation Research. 44. 79-82 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takagishi K.et al: "Absence of immunity to type II colagen and proteoglycan in osteoarthritic C57BLmice" Inflammation Research. 44. 222-226 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Takagishi,K.Maeda: "Absence of immunity to type II collagen and proteoglpan in asteoarthritis C57BL mice" Revista Espanola de Rheumatologia. 317 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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