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Percutaneous laser uncleotomy for lumbar disc herniation ; basic studies and clinical results

Research Project

Project/Area Number 05671238
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka Medical College

Principal Investigator

ONOMURA Toshinobu  Osaka Medical College, Professor, 医学部, 教授 (90025560)

Co-Investigator(Kenkyū-buntansha) YONEZAWA Takumi  Osaka Medical College, instructor, 医学部, 専攻医
米沢 卓実  大阪医科大学, 医学部, 専攻医
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Keywordslaser / disc herniation / percutaneous / vaporization / decompression / MRI / intradiscal pressure
Research Abstract

Percutaneous laser nucleotomy has been studied in authors' laser laboratory. This investigation is composed of basic studies (three parts) and the short term clinical results. Basic study 1. Dog discs were used and intradiscal pressures (IDP) and MRI findings were investigated. IDP and MRI signals were dicreasing according to laser irradiations but there were no correlations between IDP and MRI signals. Basic study 2. Goat lumbar discs were used and the heat distributions were evaluated. The temperature at the center of the nucleus pulposus rose high but the edge of the discs indicated no dangerous thermal distribution. Basic study 3. Chronic histological changes after laser irradiation were observed by light microscopic observation. These histological changes are the same as the changes of conventional study. After confirming the safety through these animal studies, we have started clinical trials of PLN for lumbar disc herniation. Results demonstrated this procedure was hopeful as an alternative to open surgery in case patient selection was carefully performed. The mechanism of pain-relief with PLN is speculated as the reduction of intra-discal pressure and/or the shrinkage of the herniated mass. The early series of PLN provided a relatively low rate of success (50%), however the procedure is relatively simple to perform, and has less associated postoperative complication. PLN is an effective, safe, short-time consuming, and less invasive treatment for protruded lumbar disc herniation in case patient selection is carefully performed. The success rate will increase with more meticulous patient selection, and it may become a more practical choice of treatment for lumbar disc herniation. Further investigation is necessary to detect the relationship between the anatomical appearance of disc and PLN outcome.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 米澤卓実・小野村敏信 他: "レーザーによる腰椎椎間板ヘルニアの治療" 医療'93. 9-NO.4. 72-75 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 米澤卓実・小野村敏信: "レーザーによる経皮的椎間板髄核の蒸散法" Monthly Book Orthopaedics. 6-NO.9. 117-119 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 米澤卓実・小野村敏信: "腰椎椎間板ヘルニアに対する経皮的レーザー髄核蒸散法" Monthly Book Orthopaedics. 7-NO.9. 47-51 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小坂理也・小野村敏信 他: "レーザー髄核蒸散法-短期臨床成績とMR画像の推移-" 臨床整形外科. 29-NO.4. 431-440 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小坂理也・小野村敏信 他: "レーザーによる経皮的髄核摘出術-chemonucleolysisとの比較-" 中部整災誌. 37-1号. 37-38 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takumi Yonezawa et al: "Therapy for lumbar disc herniation with laser" Iryou'93. Vol.9, No.4. 72-75 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takumi Yonezawa et al: "Percutaneous nucleotomy with laser" Monthly Book Orthopaedics. Vol.6, No.9. 117-119 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takumi Yonezawa et al: "Percutaneous laser nucleotomy for lumbar disc herniation" Monthly Book Orthopaedics. Vol.7, No.9. 47-51 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Riya Kosaka et al: "Percutaneous laser nucleotomy ; an evaluation of short term results and MRI findings" Clinical Orthopaedics Surgery. Vol.29, No.4. 431-440 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Riya Kosaka et al: "A comparative study of percutaneous laser nucleotomy and chemonucleolysis" Cent.Jpn.J.Orthop.Traumat. Vol.37, No.1. 37-38 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 米澤卓実,小野村敏信,他: "レーザーによる腰椎椎間板ヘルニアの治療" 医療'93. 9-NO.4. 72-75 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 米澤卓実,小野村敏信: "レーザーによる経皮的椎間板髄核の蒸散法" Monthly Book Orthopaedics. 6-NO.9. 117-119 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 米澤卓実,小野村敏信: "腰椎椎間板ヘルニアに対する経皮的レーザー髄核蒸散法" Monthly Book Orthopaedics. 7-NO.9. 47-51 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小坂 理也,小野村敏信,他: "レーザー髄核蒸散法-短期臨床成績とMR画像の推移-" 臨床整形外科. 29-NO.4. 431-440 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小坂 理也,小野村敏信,他: "レーザーによる経皮的髄核摘出術-chemonucleolysisとの比較-" 中部整災誌. 37-1号. 37-38 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 米沢卓実: "レーザーによる腰椎椎間板ヘルニアの治療" 医療'93. Vol.9 NO.4. 72-75 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 米沢卓実: "レーザーによる経皮的椎間板髄核の蒸散法" Monthly Book Orthopaedics. Vol.6 NO.9. 117-119 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshinori Ichimura: "An Experimental Studies of Percutaneous cervical Laser Discectomy -An Evaluation for the optimun irradiating condition of Nd:YAG Laser-" 10th congress international Society For Laser Surgiry and Medicine. 179-179 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小坂理也: "レーザーによる椎間板内療法-レーザー髄核蒸散法;術後成績の検討-" 日整会誌. 67(2)(3). 261-261 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小坂理也: "レーザー髄核蒸散法-MR画像の検討-" 日本脊椎外科学会雑誌. 4(1). 149-149 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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