Experimental study of etiology and therapeutics of spinal deformity
| Project/Area Number |
05671239
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
TANIDA Yasutaka Osaka Medical College, MD, 医学部, 助手 (10227233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIN Akihiro Osaka Medical College, MD, 医学部, 専攻医
ONOMURA Toshinobu Osaka Medical College, Professor, 医学部, 教授 (90025560)
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | Spinal deformity / Scoliosis / Laser nucleotomy |
|---|
| Research Abstract |
Using a new strain of Japanese white rabbits, the Lordoscoliotic rabbits (LSR), which spontaneously develop thoracic lordosis or lordoscoliosis during the growth, we studied the course, pathophysiology and treatment of spinal deformities.
1)Histopathological study : The vertebral body and disc of the abnormally curved spine were histopathologically examined in LSR at 8-48 weeks of age. The major changes observed at 8 weeks of age were translation of the nucleus pulposus and extension/compression of the annulus fibrosus. At 12 week of age, changes of vertebral growth cartilage were found. Thereafter, these changes intensify and at 24 week of age, wedging of the epiphysis was observed and at 48 weeks of age, vacuolation of the annulus fibrosus and formation of osteophytes were seen.
2)Experimental study of the resection of posterior elements for the correction of spinal deformity : At 8 weeks of age, first group of LSR were subperiosteally stripped of paravertebral muscles at the level of
… More
deformity, second group were resected of paravertebral muscles and third group were resected of paravertebral muscles, supraspinatous and interspinatous ligaments. After that, there is a tendency that the progression of the deformity in second group was raiographically lesser than in first group. There was no significant difference between in second and third group.
3)Laser nucleotomy for correction of spinal deformity : We pioneered new Neodymium-yttrium-aluminum-garnet (Nd : YAG) laser probe for animal use only which was consisted of 23 gauge needle and a bare quartz fiber, to try to correct the spinal deformity of LSR,but were not able to get effective laser irradiation. So that, we could not but relinquishing this study.
4)Laser nucleotomy for destruction of vertebral growth cartilage : LSR whose ages ranged from 16 to 20 weeks have been used. Already developed Nd : YAG laser prove which is consist of double-lumen needle and a bare quartz fiber is utilized to destroy the vertebral growth cartilage. We are now seeking the best irradiating condition. Further investigation will, we believe, be able to pray a part in the correction of scoliosis. Less
|
Report
(3 results)
Research Products
(1 results)
