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Significance of levels of serum keratan sulfate

Research Project

Project/Area Number 05671240
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKinki University

Principal Investigator

TANAKA S  Dept.Orthopaedic Surgery, Kinki University, Professor, 医学部, 教授 (00026840)

Co-Investigator(Kenkyū-buntansha) MATSUMURA F  Dept.Orthopaedic Surgery, Kinki University, assistant, 医学部, 助手 (00248014)
FUKUDA K  Dept.Orthopaedic Surgery, Kinki University, lecturer, 医学部, 講師 (50201744)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsKeratan sulfate / Articular cartilage / Osteoarthritis / Keratan sulfate / cartllage / blood
Research Abstract

Keratan sulfate (KS) is glycosaminoglycan and specifically distributed in the articular cartilage.We established the assay system and reported the alterations of serum keratan sulfate in patients of arthrosis.Our goal in this project is define the significance of serum KS levels.
To solve this problem, we first established the assay system to evaluate the cartilage degradation.Bovine articular cartilage was cultured in the presence of interleukin-1 (IL-1) and levels of glycosaminoglycans released into the media were measured.KS,chondroitin sulfate and hyaluronic acid were released with IL-1, time-and dose-dependent manner (Jpn.J.Rheumatology, in press).
We also found that superoxide anion plays an important role of maytix degration (Agents Actions, 1995).Inhibition of matrix synthesis is also important factor of matrix degradation of articular cartilage.Our KS assay system revealed the role of prostaglandin E2 (Inflammation Res.in press).
Our data obtained in this year clearly indicates that the levels of KS reflect both destruction and inhibition of cartilage matrix.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] K.Fukuda,S.Tanaka,et al.: "Hyaluronic acid inhibits interleukin-1-induced cartilage degradation" Japanese Journal of Rheumatology. In press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Fukuda,S.Tanaka,et al.: "Interleukin-1 inhibits Keratan sulfate production by rabbit chondrocytes" Inflammation Research. In press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Fukuda,S.Tanaka,et al.: "Superoxide dismutase inhibits interleukin-1 induced degradation of human cartilage" Agents Actions. 42. 71-73 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 田中清介: "変形性関節症の発症機序" 日整会誌. 68. s1184 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 斉藤政克,田中清介,他: "ヒアルロン産の軟骨プロテオグリカン代謝に対する影響" 日整会誌. 68. s1261 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高山正文,田中清介,他: "関節軟骨におけるヒアルロン酸の影響" 日整会誌. 68. s1262 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Fukuda,S.Tanaka,et al.: "Hyaluronic acid inhibits interleukin-1-induced cartilage degradation" Japanese Journal of Rheumatology. (In press).

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Fukuda,S.Tanaka,et al.: "Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes" Inflammation Research. (In press).

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Fukuda,S.Tanaka,et al.: "Superoxide dismutase inhibits interleukin-1 induced degradation of human cartilage" Agents Actions. 42. 71-73 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 田中清介: "変形性関節症の発症機序" 日整会誌. 68. s1184- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 斉藤政克,田中清介,他: "ヒアルロン産の軟骨プロテオグリカン代謝に対する影響" 日整会誌. 68. s1261- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高山正文,田中清介,他: "関節軟骨におけるヒアルロン酸の影響" 日整会誌. 68. s1262- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Fukuda,et al.: "Age-related differences in the content of antigenic and non-antigenic keratan sulfate in aggrecan from human articular cartilage" Trans Orthop Res Soc. 39. 217 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Fukuda,et al.: "Histamine H2 receptor mediates keratan sulfate secretion in rabbit chondrocytes" Am J Physiol. 34. C1653-C1657 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Fukuda,et al.: "Keratan sulfate inhibits its release in rabbit chondrocytes" Connective Tissue Res.30. 75-83 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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