| Project/Area Number |
05671275
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
WATANAVBE Hiroaki Sapporo Medical University Dpt. Anesthesiology Associate Professor, 医学部, 助教授 (20113764)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | anesthesia / surgery / adhesion molecule / sICAM-1 / ICAM-1 / tumor necrosis factor (TNF) / Interleukin-6 (IL-6) / cancer / Tumor necrosis factor (TNF) / interleukin-6(IL-6) / 手術侵襲 / 全身麻酔 |
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| Research Abstract |
Adhesion molecules such as ICAM-1 have been proposed to play important roles in the metastasis of malignant diseases. In the present study, we measured serum soluble ICAM-1 (sICAM-1) levels by ELISA in 20 abdominal malignant tumor patients (10 without metastasis and 10 with metastasis) during anesthesia. Serum sICAM-1 levels in metastatic patients were higher than those in non-metastatic patients, and their levels in metastatic patients were suppressed within 2 hours of anesthesia. To examine the regulatory mechanism in the suppression of serum sICAM-1 levels, serum interleukin-6 (IL-6) levels and serum tumor necrosis factor-alpha (TNF-alpha) levels were measured by ELISA.All serum IL-6 levels were under the detectable level, and TNF-alpha levels were depressed within 1 hour of anesthesia in 30% of patients, though serum TNF-alpha levels did not correlate with serum sICAM-1 levels. Our results suggest that anesthesia promote the attachment of cytotoxic cells to tumor cells by suppression of serum sICAM-1 level, consequently tumor cell destruction may occur especially in the patients with matastasis.
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