| Project/Area Number |
05671287
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nihon University |
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Principal Investigator |
SAEKI Shigeru Nihon University, School of Medicine, Lecturer, 医学部, 講師 (50162251)
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| Co-Investigator(Kenkyū-buntansha) |
KANAMARU Tetsuya Nihon University School of Medicine, Assistant, 医学部, 助手
OGAWA Seturo Nihon University, School of Medicine, Assistant Professor, 医学部, 助教授 (80096792)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | somato-sympathetic reflex / alpha 2 agonists / Clonidine / Medetomidine / α2-agonist / atipamezole / alpha_2-agonist |
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| Research Abstract |
We studied the analgesic and cardiovasucular effect of intrathecally administered alpha 2 adrenoceptor agonists, clonidine and medetomidine, using somato-sympathetic reflex as a parameter. Concerning for clonidine, intravenous administration was studied and the same parameters were also evaluated.
(Method)
Somato-sympathetic reflex potentials (A and C reflex potentials) which were derived from lumbar sympathetic ganglion of cats by electrical stimulation of femoral nerve were induced. Alpha-2 agonists were administered from intrathecally implanted PE-10 catheter or intravenous line in the forearm.
(Result)
1. Intrathecal administeration of clonidine
(1) Decreased A reflex potential proved that clonidine makes a role of hypotention and bradycardia.
(2) Decreased C reflex potential indicates that clonidine act as an analgesic by central mechanism involving spinal cord.
2. Intravenous administeration of clonidine
(1) Intravenously applied clonidine also showed similar results as intrathecal clonidine.
(2) Temporal hypertension observed in high dose of clonidin was thought to be elicited by activation of alpha 1 or alpha 2 receptors in peripheral vasculature.
3. Intrathecally applied medetomidine also affects sympathetic reflex potentials and act as an analgesic by central mechanism involving spinal cord.
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