| Project/Area Number |
05671330
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kochi Medical School (1995)
Yokohama City University (1993-1994) |
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Principal Investigator |
SHUIN Taro Kochi Medical School professor, 医学部, 教授 (80179019)
|
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| Co-Investigator(Kenkyū-buntansha) |
穂坂 正彦 横浜市立大学, 医学部, 教授 (30106330)
窪田 吉信 横浜市立大学, 医学部, 助教授 (10106312)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | renal cell carcinoma / von Hippel-Lindau gene / p53gene / retinoblastoma gene / 癌抑制遺伝子 / von Hippel-Lindau病遺伝子 / 腎癌 / Retinoblastoma遺伝子 |
|---|
| Research Abstract |
Human cancers develops in a multistep processes. Activation of oncogenes and inactivation of tumor suppressor gene is associated in each process. Our purpose in the present study is to clarify these processes in human renal cell carcinomas. For that purpose we examined the mutations and loss of heterozeigosity in 3 tumor suppressor genes, namely von Hippel-Lindau (VHL) gene, p53 gene, and retinoblastoma gene, using molecular biology techniques. W detected a high insidence of mutation as well as loss of heterozeigosity in VHL gene. The other two tumor suppresssor gene showed low frequency of mutations. This result suggest that VHLgene is a major tumor suppressor gene in human kidney cancers.
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