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Study of the neutrophil functions in pregnancy

Research Project

Project/Area Number 05671357
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

ARAI Takashi  Toyama Med. & Pharmaceut. Univ. Faculty of Med. Ass. Prof., 医学部, 講師 (90111492)

Co-Investigator(Kenkyū-buntansha) SOEDA Yoshikatu  Toyama Med. & Pharmaceut. Univ. Faculty of Med. Aists. Prof., 医学部, 助手 (40216578)
今井 敏啓  富山医科薬科大学, 医学部, 助手 (80176479)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
KeywordsPregnancy / Neutrophil / Toxemia of pregnancy / Leukotriene B4 / Arachidonic acid / Phospholipid / Neutrophil elastase / Chemotaxis / 好中球 / エラスターゼ / 走化性 / 性ステロイド / インターロイキン1β / 正常妊婦 / ロイコトリエンB_4 / カルシウムイオノフォア
Research Abstract

(1) Calcium ionophore-induced leukotriene B4 release from neutrophils is suppressed in 2nd and 3rd trimester of normal pregnancy but not in toxemic pregnancy.
(2) Released amounts of leukotriene B4 from neutrophils of toxemic patients are at identical level with nonpregnant women and significantlly correlated with birth weights and its z scores at each gestational age.
(3) Arachidonic acid content and mole% in phospholipids of neutrophils decreased with gestational weeks.
(4) Ratio of unsaturated fatty acid/saturated fatty acid decreased with gestational weeks.
(5) These findings suggest that the neutrophil activation is suppressed in normal pregnancy in terms of leukotriene B4 release and of the fluidity of the membrane and that disorders of these mechanism seem to induce toxemia of pregnancy.
(6) Elastase contents of neutrophils and PMA-stimulated elastase release from neutrophil are not different among pregnant, non-poregnant woman and men.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 今井敏啓,新居隆: "妊娠経過と好中球ロイコトリエンB4-正常妊娠と妊娠中毒症における量的変動-" 日本産科婦人科学会雑誌. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Toshihiro IMAI and Takashi ARAI: "Quantitative changes in Leukotriene B_4 Relases in neutrophilic leukocytes activated by Ca ionophore during pregnancy-Normal pregnancy and Preeclampsia-" Acta Obstetrica et Gynaecologica Japonica. 48. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published: 1993-04-01   Modified: 2016-04-21  

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